I have Fibro and Lyme as well as CFS.
I chose to try Pregnenolone since it is supposed to make whatever hormones you are deficient in and only that and will not make too much of something you don't need, so I felt it was better than taking the individual hormones downstream of it, since I could be getting too much of them.
Pregnenolone made me happy again. It made me nice again.It made me tolerant and able to brush off stressful people's comments again. It took away my secondary depression and most of my Lyme rages, so I could be around people without fear of blowing up at them.
Unfortunately, it also brought back the migraines I'd had before menopause, since it had raised my low postmenopausal estrogen back to those levels, even on a small dose. Narcotics are incompatible with my blood pressure meds, making me stop breathing, so I had to lower the pregnenolone drastically. I had the kind of hormonally induced migraines that cause the most pain, and will make you stroke out if not knocked out completely with sleeping pills and narcotics.
I had started at 30 mgs. daily, which is a low dose, and after a migraine sent me to the Emer. Rm., I lowered it to 30 mgs. 3 X week, which is where I still got such great results, but my estrogen was still at premenopausal levels and caused migraines. This shows once again how sensitive we are, since many people start at 50 mgs. daily and go up from there!
I am now on 5 mgs. 3 X week. That helps me to be around people I like, and I get no migraines. I still have to avoid anyone I really don't like, but I don't think I'd still be married without it. I am afraid Codex will take it away from me, when they finally get around to enforcing it, since they've said they will take away hormone supplements first.
It is said to also improve cognitive function, but I guess I am not taking enough to notice that. My cognitive abilities are still going downhill.