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Anyone tried SAMe who have CBS upregulation?

Bdeep86

Senior Member
Messages
278
I am needing a methylation shortcut, and I have issues with acetylcholine and cortisol so its hard for me to use the choline based recommendations. However, I have bad issues with CBS, I have heard that SAM can effect CBS doesn't anyone know if SAMe supplements aggravate CBS issues?
 

Bdeep86

Senior Member
Messages
278
TMG seems to give me low cortisol symptoms and I don't feel that great on it so I am thinking to try some SAMe
 

UM MAN

Senior Member
Messages
106
Location
Florida
I take 200mg of SAMe around 8pm. I feel like it improved my sleep.
400mg of SAMe interfered with my getting to sleep. I'm a freak..
 

ahmo

Senior Member
Messages
4,805
Location
Northcoast NSW, Australia
Bdeep86, I had reactions to both SAMe and NAC before I knew anything about CBS and sulfur issues, or about methylation. Both of these supps were excitotoxins for me. ahmo
 

Critterina

Senior Member
Messages
1,238
Location
Arizona, USA
Bdeep86, I had reactions to both SAMe and NAC before I knew anything about CBS and sulfur issues, or about methylation. Both of these supps were excitotoxins for me. ahmo
ahmo,
Do you mind saying what kind of reactions? I'm trying to figure out what symptoms go with what problems. I've been on Me, NAC, and ALA up until finding I'm CBS.
 

ahmo

Senior Member
Messages
4,805
Location
Northcoast NSW, Australia
ahmo,
Do you mind saying what kind of reactions? I'm trying to figure out what symptoms go with what problems. I've been on Me, NAC, and ALA up until finding I'm CBS.
At that time I got very twitchy, anxious/agitated. And I see now that I was already overflowing with thiols. These days when I get too much sulfur I have an eczema flare.
 

Critterina

Senior Member
Messages
1,238
Location
Arizona, USA
At that time I got very twitchy, anxious/agitated. And I see now that I was already overflowing with thiols. These days when I get too much sulfur I have an eczema flare.

Thanks. I got the eczema flare, too, every time I drank red wine. And recently, too, after 3 months of Me and NAC. Not twitchy, though. Liver area has been achier and belly slightly distended; I was trying to pin that to sulfur. Maybe not.