I am taking ketamine right now. My brother is a psychiatrist--tho not mine--and he started using ketamine several years ago. I am very cautious and I was too scared to take it for a long time. Plus, my other meds were doing the trick. I am twice blessed with having BipolarII Syndrome and Chronic Fatigue Syndrome. The BPII is going on 30 years; the CFS for four. There are major sleep issues with both illnesses. When my current meds weren't up to the CFS, I reconsidered taking ketamine. At that time, my sleep was just a mess. I was waking up 10-12 times a night, maybe more, and not getting deep sleep at all. I was miserable.
I started the ketamine out at 10 mg as a nasal spray. I worked my way up to 40 mg. Then we doubled the dosage. In a CFS moment, I forgot that and jumped straight to 80 mg. In retrospect, that was good, as every time I went up I would get nervous. Now I am at 90 mg and should stay there for awhile. My first sequence of sleep--about 6-7 hours is great, usually with just one awakening. Since I have CFS, I sleep 12 hours, so the second sequence is more problematic, as I still have medicine in my system. I used to take one 10 mg, then 20 mg, spray before going back to bed. The results were sketchy. I think a nasal spray just isn't completely stable. So, now I am doing a 10 mg pill and it is working better.
I will always be careful with ketamine. I alway read the label--for correct dosage--before I take it, but I have read that it is actually a mild drug. My brother is convinced it is the next big drug for depression of the decade. He told me of a woman who had such bad BiPolar II that she had tried everything. After 3 ketamine infusions, she was cured. Obviously, this will not work for everyone, but if I were struggling with BPII the way I used to, I would say, "Sign me up!" I still might.
Bottom line: I used to dread going to bed; with ketamine, I look forward to it.