I'm being tested, after my presumed Type 2 diabetes diagnosis from last week was followed by protracted hyperglycemia, ketonuria, nasty headaches, and diarrhea. I should have the results in a few weeks.
Damn. Sorry to hear that.
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I'm being tested, after my presumed Type 2 diabetes diagnosis from last week was followed by protracted hyperglycemia, ketonuria, nasty headaches, and diarrhea. I should have the results in a few weeks.
I'm being tested, after my presumed Type 2 diabetes diagnosis from last week was followed by protracted hyperglycemia, ketonuria, nasty headaches, and diarrhea. I should have the results in a few weeks.
I do have an exaggerated startle response, but only when something else is already wrong. Usually not.Do you (or did you) ever have an insane startle reflex or any symptoms that related, even on a minor scale, to SPS (Stiff Person Syndrome)?
Sort of. It's more that Type 1 has no insulin production. But that usually occurs due to detected auto-antibodies. I've been reading a lot about this the past few days, because my case seems to be very atypical, and my GP is completely clueless.@Valentijn I am also sorry to hear this and please keep us posted if it turns out that you are positive for GAD65 autoantibodies. My understanding (which could be completely off) is that the GAD65 Abs relate to the Type 1 autoimmune form of diabetes vs. Type 2.
so, I just recieved results from Mayo that my serum tested positive for GAD65 antibodies ( 0.05 nmol/L. ......reference values are <(or equal to) 0.02nmol/L).
I have a exaggerated startle response, although less than @Gingergrrl.
I am starting to accumulate a few rather unusual positive labs... that don't quite point anywhere yet.
I wonder if my doc would know what GAD antibodies are.......
I would think so b/c it's not a rare/obscure autoantibody like the tests I did from Cell Trend which are not recognized by US Neuros. GAD65 can be a marker for diabetes (which I don't have), for Stiff Person Syndrome (SPS) which I now know I don't have, or for dysautonomia & other autoimmune conditions like Hashimoto's (both of which I do have).
GAD65 obstructs the conversion of glutamate to GABA so for me it was triggering this insane startle reflex and symptoms that were like a minor version of SPS but since IVIG, that has completely disappeared after about 2 yrs of being tortured w/it.
So I think most docs would know of GAD65 (even if they only knew of the diabetes and SPS connection and nothing else).
I have at least 4 homozygous on GAD1 that Livewello shows up
As far as I recall, the GAD1 SNPs identified by programs like Livewello have no effect. Just having SNPs doesn't mean anything, it depends on which SNPs they are.
@Paralee, I think it's worth asking and I only mentioned diabetes b/c this is the first thing most doctors think of the with GAD65 autoantibody. My Endo has ran every diabetes test possible on me and I am negative on them all so we know I have the GAD65 Auto-Ab for another reason (at least so far).
Do you have an extremely exaggerated startle reflex? Mine reached the level that just our doorbell or an every day sound could startle me for hours. Our fire alarm went off and we think it triggered a "startle seizure" (but no definitive proof of this). Since high dose IVIG, the startle reflex disappeared. I was at a restaurant w/family back in Nov and someone dropped a tray which shattered on the ground and it didn't even phase me. My family was in awe b/c prior to IVIG, that would have triggered a reaction with tachycardia, full body shaking, teeth chattering, confusion, difficulty speaking, muscle cramping/shaking, etc. And now, nothing. So I know the IVIG is lowing this antibody. There is no other explanation.
As far as I recall, the GAD1 SNPs identified by programs like Livewello have no effect.
Just having SNPs doesn't mean anything, it depends on which SNPs they are. You would need to check whetehr there is any research showing that your SNPs have an effect on the enzyme.
@Gingergrr, I have had the startle reflex off and on, not so much the last few years, but if my head would open back up I might. This is interesting, I have always heard/read that the startle reflex was low adrenals.
To followup on myself, I tested negative for GAD.I'm being tested, after my presumed Type 2 diabetes diagnosis from last week was followed by protracted hyperglycemia, ketonuria, nasty headaches, and diarrhea. I should have the results in a few weeks.
To followup on myself, I tested negative for GAD.