I wish i could add something to the technical side of the discussion but i don't understand the whole Acetylcholine, Muscarinic mechanism very well.
I would like to stress again that Citicoline has a major positive effect on my pain and energy symptoms of cfs.
To the point where my body feels pain free, clear and ready for action when i am taking it.
Its quite dramatic and curious.
But...in me at least, its negative effects of depression are intolerable. That leaves me somewhere between elated and despairing.
Maybe i have some genetic issue which makes it cfs-effective in me, so i wouldnt want to ram it down peoples throats.......On the other hand, maybe it deals with some common pathological problem in me/cfs(?)
Today i took a very small amount of citicoline sublingually and got a noticeable but more modest effect of both positive and negative. This may be a workable regime for me. I have to investigate the half life of citicoline, its interactions with other supplements/drugs or possible choline/phospholipid(?) alternatives.
One suggestion i got was perhaps upping an antidepressant to offset the depressive effects, or adding a muscarinic antagonist. This might be a good option. Rich Van mentioned scopolamine, but there may be many other choices.
Rich Vank discussed phospholipids ;
Given that the methylation cycle appears to be partially blocked in many or most
cases of CFS, use of citicoline might be a way to expedite the
replacement of phospholipids that have been damaged by oxidative
stress in CFS.
My bottle of Jarrows Citicoline says, ' Citicoline consumption promotes brain metabolism by enhancing the synthesis
of acetylcholine, restoring phospholipid content in the brain....'.
Maybe its the phospholipid action that is proving effective, in which case, i could take alternatives ?
I've got a lot of reading to do.
