gettinbetter
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Has anyone here used Hyalauronic Acid
If so what were the effects ?
Thanks
If so what were the effects ?
Thanks
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Has anyone here used Hyalaronic Acid
There is a difference between high molecular weight hyaluronic acid and low molecular weight hyaluronic acid, this paper says high MW is anti-inflammatory regarding macrophage activation, whereas low MW is pro-inflammatory. Which is more appropriate for ME/CFS is not clear.
Only small amounts of oral high MW hyaluronic acid are actually absorbed, according to this study. The rest is broken down by stomach acids and digestion. Low MW hyaluronic acid is well-absorbed, says this study.
High MW hyaluronic acid is found to reduce microglial activation by its effects on modulate TLR-4 (in this respect, it may have a similar action to low-dose naltrexone, which also acts via TLR-4).
Other studies put to rest the notion the myth that high molecular weight HA can't be absorbed well.
Would you have some links to those studies? I just this 2016 study which says high MW hyaluronic acid is "degraded to oligosaccharides by intestinal bacteria, and oligosaccharide HA is absorbed in the large intestine and is subsequently distributed throughout the tissues, including the skin."
So you are getting what they refer to as oligosaccharide hyaluronic acid, rather than hyaluronic acid.
study found just taking around 1000 mg liposomal C daily will saturate the skin within month or so. I didn't know that. It will lessen age spots too.
Would you be so kind and share the link to that study?
I'm very interested, since until now I only found studies comparing different levels of vitamin C from different products in plasma. For example posted here: https://www.longecity.org/forum/top...-term-systemic-health/?view=findpost&p=855510
Haven't yet found even one study which tested levels in any tissue (comparing different products).
the specific place I read it but here is this
interesting thing about liposomal vitamin C is that it obsoletes topical vitamin C serum on skin. Study found just taking around 1000 mg liposomal C daily will saturate the skin within month or so.
Sadly, also doesn't support in any way the notion that liposomal has a higher absorbtion than regular oral in plasma.
Liposomal according to Dr. Levy is up to 10 times as effective as oral ascorbic acid in his clinical experience. But he also makes it clear that only applies to infections, and not any of the many other health effects of vitamin C. Studies which tested equal amounts of ingested liposomal and regular oral found both produced equal plasma levels. Liposomal very likely has better uptake in cells, but since this has never been tested comparative to regular oral vitamin C, any such marketing claims are unsupported by studies.
I rather stick with regular high dose ascorbic acid which has many beneficial health effects in my experience, than spend too much on expensive liposomal, since I don't have obsolete money.
Also 'vitamin C saturation' is a myth, as the one study found in my linked to post shows.
C is very INEXPENSIVE ... around $20 for a 90 day supply at 1400mg daily
you think the average person relishes swallowing 10-20 or more capsules a day of vitamin C
liposomal C gets way more positive reviews from people than regular C ever got.
Never told you to bother, you do what you want ... I was just discussing cost of liposomal C coming down in price