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Created in 2008, Phoenix Rising is the largest and oldest forum dedicated to furthering the understanding of and finding treatments for complex chronic illnesses such as chronic fatigue syndrome (ME/CFS), fibromyalgia (FM), long COVID, postural orthostatic tachycardia syndrome (POTS), mast cell activation syndrome (MCAS), and allied diseases.
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Raises 2 questions :So I have used hydrocortisone for the last 3-4 years. I believe my specialist used it as support for my adrenals not really as a immune suppressor or anti inflammatory. Basically he wanted to start working on my gut first but I kept showing up to my appointments falling asleep in the waiting room. I was falling asleep driving my car with an infant. My primary care at the time did jack sh*t which was ridiculous.
My specialist decided to work on the gut and do the hydrocortisone at the same time.
My specialist took one look at me after I had come in twice and put me on hydrocortisone and suddenly I could function like a normal human again. I had trouble with the dosing for a while. I kept having flare ups and couldn't quite figure out how to stop them before they got bad. I just started IVIG and after the first treatment I was able to cut my dose in half to 2.5mg. At the highest I was on probably 15mg daily. Hopefully this info helps! Like I said it wasn't a magic pill but it definitely was a game changer for my quality of life.
Does hydrocortisone raise serum levels of cortisol.
And do me/cfs people have a dulled response to cortisol. My cortisol (2 tests) is normal, but perhaps my response to it (after various stressors) might be dulled.
I took 2 g of Tinidazole 6 days ago and urinary symptoms immediately resolved.
I also notice that no new bruise appeared and old ones seems to resolve quicker than previously
Tinidazole is efficient against protozoa and anaerobic bacteria (most anaerobic bacteria are in the gut or the genital tract or the mouth), so I wonder if I have any latent infectious/parasitic problem that may be a trigger for my CFS/ME...
Do you think that you may have acquired any new infections due to some immunosuppression from the prednisolone?
I think something latent in my body showed up and flared with the immunosuppression I induced with corticosteroids. I think it's a bacteria or a protozoa, because it seems sensitive to tinidazole.
When I took 2 g Tinidazole, I spent three bad days with head pain form the drug, followed by one perfect day where I felt .... normal...(feeling normal is not normal for any ME/CFS patient!).
NSAIDS are hard on gut, liver, and mitochondria.
Okay, it was the prednisone that made me feel great. I had a second round of prednisone not too long ago and was able to replicate the great daytime feelings but again with even more sleeplessness and increased appetite.After reading the entries here, I am mot sure if my improved feelings (stamina, burning, aches) is not because of starting LDN but because I took prednisone as immunosuppressant for my suspected drug reaction to nurtec (all over body itchy raised rashes since 7 days ago). I am on day 3 of 7 day course of prednisone, while on day 2 of LDN.
Will report back...
I had a second round of prednisone not too long ago and was able to replicate the great daytime feelings but again with even more sleeplessness and increased appetite.
@Hip is there a link to the discussion about a PEM shield through using prednisone?
One can take hydrocortisone every day. Mestinon had allergens so many of us can't take it. It's also prescription only, making it out of reach for many. Huperzine A works better, without alleegend and with fewer side effects. Even so, many of us are also on beta blockers or other drugs.A few people have virtually eliminated their PEM using Mestinon, which unlike corticosteroids is something you can take every day. See the PEM busters thread for info.
It might be helpful to do a 24 hour saliva or urine cortisol test. If it's low early in the day to late afternoon, then hydrocortisone might be helpful. A replacement dose is around 25mg, which can be taken in multiple smaller doses throughout the day to provide the function that someone with normal cortisol would have.And I suspect the same thing about corticosteroids. I do know some people who use them just to attend a special event. I prefer methylphenidate (low dose on occasion only) because I am familiar with the effects.
Inhibition of mitochondrial respiratory chain in the brain of adult rats after acute and chronic administration of methylphenidate
Ana O Fagundes et al.
Neurochem Res. 2010 Mar.
Methylphenidate (MPH) is frequently prescribed for the treatment of attention deficit/hyperactivity disorder. It was previously demonstrated that MPH altered brain metabolic activity. Most cell energy is obtained through oxidative phosphorylation, in the mitochondrial respiratory chain. However, there are still few studies about MPH effects on the brain of adult rats. Thus, in the present study we evaluated the effect of acute or chronic administration of MPH on the activities of mitochondrial respiratory chain complexes I-IV in the brain of adult rats. For acute administration, a single injection of MPH was given to 60-day-old rats. For chronic administration, MPH injections were given to 60-day-old rats once daily for 28 days.
Our results showed that complexes I, II, III and IV were inhibited after acute or chronic MPH administration in the hippocampus, prefrontal cortex, striatum and cerebral cortex. On the other hand, cerebellum was not affected.
One can take hydrocortisone every day.
Huperzine A works better
Okay, it was the prednisone that made me feel great. I had a second round of prednisone not too long ago and was able to replicate the great daytime feelings but again with even more sleeplessness and increased appetite.