Amy Proal - Interview with Dr. Resia Pretorius: LongCovid microclots and Hypercoagulation

[Violeta]

While looking at information about the hypothalamus, I found this study about the hypothalamus with relation to coagulation of the blood.

"Under conditions of chronic experiment, the stimulation of alpha- and beta-adrenergic structures of the posterior hypothalamus was performed. The same procedure was repeated after inactivation of these structures. The results of experiments have shown a specificity of the influence of alpha- and beta- adrenergic structures upon the separate blood coagulation phases and the heterogeneity of those structures distribution in the posterior hypothalamic region."

https://pubmed.ncbi.nlm.nih.gov/1964643/

I thought it might pertain to this topic because:

"The present article reviews the possible routes and mechanisms of neuroinvasion of SARS-CoV-2, with a specific focus on the role of the hypothalamic circuits in mediating the neurological symptoms noted during COVID-19 infection."


https://www.ncbi.nlm.nih.gov/labs/pmc/articles/PMC8002703/

 

[perrier]

Excellent piece by Dr Pretorius in The Guardian

https://www.theguardian.com/commentisfree/2022/jan/05/long-covid-research-microclots

She mentions ME.
Have we any news from OMF regarding microclots, or what Dr. Davis found in the blood? Anyone know? Thanks.

 

[Akasha]

Regarding the fluorescence microscope for Dr. Davis, the last I saw on @Janet Dafoe twitter was from December:

https://twitter.com/i/web/status/1469411673857347584

Whitney has a spotfund fundraiser that seemed to reach its goal a couple of days ago (don't know if that amount is enough, I doubt it). You can still donate to it (here's the link).
You also can make a donation to OMF and ask it to be directed to Ron's microscope. That's what I did on Giving Tuesday.

Excellent piece by Dr Pretorius in The Guardian

Thanks for the link, nice summary.

 

[Violeta]

The australian researchers Sonya Marshall Gradisnik and Donald Staines have been looking at the TRPM3 ion channels, they think dysfunction here is whats causing me/cfs. These receptors are found through out the body and govern calcium transport to many cells but also to e.g mitochondria. Calcium transport needs to happen exactly at the time needed by the cell, not slightly later, so dysfunction here has potential to cause big problems even if we have perfectly fine calcium levels in our blood.

https://pubmed.ncbi.nlm.nih.gov/31014226/
https://www.frontiersin.org/articles/10.3389/fimmu.2019.02545/full

Interresting info on the viral proteins btw!

From the study listed above:

" In the present study, we aim to confirm the previous results describing an impaired TRPM3 activity in a new cohort of CFS/ME patients using a whole cell patch-clamp technique after modulation with reversible TRPM3 agonists, pregnenolone sulfate and nifedipine, "

It lists two TRPM3 agonists.

I wonder if Gradisnik and Staines have any new information.

 

[Consul]

I wonder if Gradisnik and Staines have any new information.

They were part of some conference not too long ago but i havent seen any of it, not sure if its available somewhere.

 

[HealingFalcon]

Good luck with the attempt! I'm not quite clear on the accuracy of the light microscopy technique. I presume it is cruder and much more prone to artifact. ...

I was fortunate enough to have them demonstrated precisely per the Pretorius protocol by an expert. They look like the Professor's published images. (She also saw my images and they received a "thumbs-up").

Although you did not look for the clots by yourself, do you happen to know if this microscope would be sufficient for this procedure? I plan to look for microclots and compare my blood with my twin sisters...