Hi everyone,
I wonder if the dysfunctional enzyme added by Robert Phair to his Metabolic modeling could be the AMP-activated protein kinase.
This enzyme is present in every cells in our body.
At the Unrest screening in France, Ph De Korwin (the president of the French scientific CFS research) said that they are certain that an enzyme was responsible for all the problems found in many studies (immunes abnormalities with lack of T cell regulation, metalobic finding ...).
He works with a team specialized in data analysis from studies publied on pubmed. This type of massive analysis looks for similar finding/abnormalities in studies.
He didn't said that the enzyme which he think responsible for our symptoms is AMPK, but I wonder if he supposes that.
Given the finding of this study
https://www.ncbi.nlm.nih.gov/pubmed/29654166
AND
After reading this article :
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4855276/#!po=17.5000
I wonder if DIRECT Ampk activators (not metformin) can help.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4855276/table/tbl2/?report=objectonly
INDIRECT Ampk activators works by increasing AMP/ATP ratio by the complex 1 mitochondrial respiratory chain for the majority, which seem problematic in ME.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4855276/table/tbl1/?report=objectonly
I wonder if the dysfunctional enzyme added by Robert Phair to his Metabolic modeling could be the AMP-activated protein kinase.
This enzyme is present in every cells in our body.
At the Unrest screening in France, Ph De Korwin (the president of the French scientific CFS research) said that they are certain that an enzyme was responsible for all the problems found in many studies (immunes abnormalities with lack of T cell regulation, metalobic finding ...).
He works with a team specialized in data analysis from studies publied on pubmed. This type of massive analysis looks for similar finding/abnormalities in studies.
He didn't said that the enzyme which he think responsible for our symptoms is AMPK, but I wonder if he supposes that.
Given the finding of this study
https://www.ncbi.nlm.nih.gov/pubmed/29654166
AND
After reading this article :
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4855276/#!po=17.5000
I wonder if DIRECT Ampk activators (not metformin) can help.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4855276/table/tbl2/?report=objectonly
INDIRECT Ampk activators works by increasing AMP/ATP ratio by the complex 1 mitochondrial respiratory chain for the majority, which seem problematic in ME.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4855276/table/tbl1/?report=objectonly