Interesting,
I just read Fluge's study on the impaired pyruvate dehydrogenase function and they found that PDK1, PDK2 and PDK4 RNA are elevated.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5161229/
Pyruvate dehydrogenase kinase or PDK' is a class of enzymes that inhibit pyruvate dehydrogenase.
"PDK1–PDK4 are regulated at the transcriptional level via signaling cues involving factors such as AMP-dependent protein kinase (AMPK) (22), PPARs (23), and HIF1 (24)."
The AMPK enzyme is directly related to PDK '
If the mysterious factor in the serum was an enzyme (AMPK or an other) ?
If I remember correctly, Ron Davis said it was probably a protein which cause the increase of impedance. An enzyme is a protein.
I don't know if it's possible to just test the buffy coat to see if lymphocytes or monocytes can be implicated in the rise of impedance.
For me, we may well have an dysfunctional (I don't like this term) enzyme that causes all our problems. But which ? For which subgroup?
I just read Fluge's study on the impaired pyruvate dehydrogenase function and they found that PDK1, PDK2 and PDK4 RNA are elevated.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5161229/
Pyruvate dehydrogenase kinase or PDK' is a class of enzymes that inhibit pyruvate dehydrogenase.
"PDK1–PDK4 are regulated at the transcriptional level via signaling cues involving factors such as AMP-dependent protein kinase (AMPK) (22), PPARs (23), and HIF1 (24)."
The AMPK enzyme is directly related to PDK '
If the mysterious factor in the serum was an enzyme (AMPK or an other) ?
If I remember correctly, Ron Davis said it was probably a protein which cause the increase of impedance. An enzyme is a protein.
I don't know if it's possible to just test the buffy coat to see if lymphocytes or monocytes can be implicated in the rise of impedance.
For me, we may well have an dysfunctional (I don't like this term) enzyme that causes all our problems. But which ? For which subgroup?
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