I think my alcohol intolerance is more due to the histamine content and my twitchy mast cells, as I've had it since I was a very small child (I didn't develop ME until I was 17). If my Dad gave me a medicinal sip of brandy, or I was dared by my cousin to sneak a swig of our Nan's sherry, I'd flush burning scarlet from the shoulders upwards, and quickly begin to feel nauseous and headachey. I'm nearly 60 now, and I still do! I've never in my life managed to drink enough to get a hangover.