I used Tramadol for years for CFS systemic pain. No problem other than minor withdrawal symptoms for a few days when stopped. The neurologist rxd Topiramate for buildup for ongoing neurological pain. It didn’t work fast enough for me. More recently I saw a pain clinic (MD’s) for peripheral neuropathy, which pain has elevated in feet needing quick acting relief. Percocet (in several strengths) works but it’s got acetaminophen in it; the purer pain relief part, OxyCodone can be rxd itself. I also got rxd Methadone but haven’t started it yet. It’s a class II drug meaning more restricted use and monitoring but it’s supposed to be effective for all day pain relief.