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Created in 2008, Phoenix Rising is the largest and oldest forum dedicated to furthering the understanding of, and finding treatments for, complex chronic illnesses such as chronic fatigue syndrome (ME/CFS), fibromyalgia, long COVID, postural orthostatic tachycardia syndrome (POTS), mast cell activation syndrome (MCAS), and allied diseases.
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To my knowledge homocystein reflects both the levels of B12, folates and B6 so there are other deficiencies that could also be a possibility. Just a thought.BUT since studies show that CFS patients also have high homocysteine in their brain and cerebral cortex fluid, it also means that they still lack methyl cobalamin for other unknown reason, since not all the CFS patients have vitamin D deficiency.
Amazing. And as B12 doesn't have any known adverse effects, even in regular high doses, you can possibly do this regularly.
Here some observations concerning methyl and adenosylcobalamin injections.
Methylcobalamin:
Helps with ability to concentrate and maybe improves a little my memory. Doesn't help with my muscles and doesn't give energy to my brain. Doesn't help with headache or other MCAS of CFS symptoms, not atleast after four injections. 5mg shot once in seven days. It seems that in my case I can inject maybe once in two weeks, since there are no symptoms coming back with during those seven days.
Adenosylcobalamin:
Helps even more with ability to concentrate and learn and also helps with remembering things. My brain fog is totally gone after the first injection. It is wonderfull to see the world like a normal healthy person sees it after almost eight years with brain fog. I have gene mutation called COMT 472A which may hinder my dopamine, epinefrin and noradrenalin production causing also higher levels of homocysteine in brains. Adenosylcobalamine injection has also affected to my dopamine production since I now have felt happyness, which I haven't felt for a long long time. I have now only injected once 1mg and that was three days ago. I can ztill feel happyness and no brain fog yet. This cobalamin didn't help with other symptoms, atleast not yet.