When you started Abilify did you try to see if much lower dosages worked? I have this feeling that for some pwME, dosages >= 2 mg will become more antagonizing/blocking at dopamine and serotonin receptors and also speed up tolerance.
Abilify achieves quite high dopamine receptor occupancy throughout the brain even at lower dosages, with ~70% occupancy already at 2 mg, ~50% at 1 mg, and ~30% at 0.5 mg.
Abilify has very high affinity for D2/3 receptors, very long half-life, and slow dissociation from receptors, so I imagine with high fraction of receptor occupancy even as low as 2 mg it could be that in some people it becomes more dopamine blocking?
I wonder if you had stayed at something like 0.5-1 mg how things would’ve transpired.
