Abilify- Stanford Clinic Patients

[Strawberry]

Sorry, I can’t read 55 pages to see if this has been answered. Would abilify work for moderate also? Or is it only recommended for the severe and very severe?

Any reason why a moderate shouldn’t take … 0.25? Are there risks?

 

[mitoMAN]

I think moderate often report longer lasting benefits. Start at 0.25 and work up to 2mg slowly

 

[flitza]

That's interesting, but also a little strange.

Agonism of 5-HT1A and 5-HT2A by drugs like LSD, DMT, mescaline and psilocybin induces potent psychedelic trips.

You would think the last think a schizophrenic needs is psychedelic effects.



I got interested in 5-HT1A and 5-HT2A because of the reduction of expanded consciousness / spiritual feelings that I began to suffer from after being hit with ME/CFS. I wanted to figure out why ME/CFS and brain fog can so dampen higher consciousness, and 5-HT1A and 5-HT2A looked like they might be the culprits, as these receptors have been linked to transcendent personal experiences.

There is apparently a reduced number of 5-HT1A receptors in ME/CFS.

I just started reading about this subject here, now and the statement about heightened colors caught me. I suffer at times with heightened color sensation red, yellow and white and green- I notice it most with traffic lights- and attributed it to generalized neuroinflammation. I do not take any of the abovementioned antipsychotics. Now, I wonder if the mechanism or area of inflammation could be similarly explained.

 

[Yuno]

RP5063, an atypical antipsychotic drug with a unique pharmacologic profile, improves declarative memory and psychosis in mouse models of schizophrenia

I’m sorry, but too sick to read the papers. Are you saying this could be a promising alternative to Abilify?

 

[Boba]

I just started Abilify 0,25mg. I am taking Doxepin for sleep besides it. I don’t have a clear strategy. I will not change anything about my daily routines to see what it does. My symptoms are Fatigue, PEM, some twitching and brain fog.

 

[leokitten]

I’m sorry, but too sick to read the papers. Are you saying this could be a promising alternative to Abilify?

Yes totally. Brilaroxazine is like Abilify or even with better binding profiles, but without the very common metabolic and endocrine side effects that plague Abilify and other antipsychotics.

 

[Strawberry]

Is brilaroxazine currently available?

 

[leokitten]

Is brilaroxazine currently available?

Starting phase 3 trials for schizophrenia this summer. If phase 3 as successful as phase 2 then will be FDA approved and avail 2025.

But in 2025 indication won’t be for antidepressant add-on so might be more difficult to get it paid for by insurance for ME. Reviva Pharm is also working for different indications for brilaroxazine and are in various clinical phases for those.

 

[Martin aka paused||M.E.]

My father had an interesting talk to a ME/CFS-doc yesterday. He says that even normal doses(not low doses) work in ME/CFS. He found out when he had one patient with shizophrenia who also suffers from ME. It improved both. Now he says, his patients improve more on doses around 10mg. How success rates would be around 70-80%.

 

[Strawberry]

Martin are you going to up your dose then? with that information I’d keep titrating up slowly.

 

[Martin aka paused||M.E.]

Martin are you going to up your dose then? with that information I’d keep titrating up slowly.

I would never take 10mg... Just found it in interesting to know

 

[Hipsman]

OK, so I have been taking abilify for more than a week now, increased the dose from 0.25mg to 0.5mg daily, will continue increasing it by 0.25mg every week till I reach 2mg. Also planning to start Amisulpride 12.5mg daily in few weeks because why not.

The restlessness feeling disappeared around day 5, no sleep problems anymore or other side-effects.

Feel significantly more energy and a bit less brain fog, before abilify I was going for a walk every day for around 35-45 minutes, now I go for 60-70 minutes walk, brain fog still remains my worst symptom, the improvement isn't really that significant, hopefully when I reach 2mg that will change for better.

 

[leokitten]

OK, so I have been taking abilify for more than a week now, increased the dose from 0.25mg to 0.5mg daily, will continue increasing it by 0.25mg every week till I reach 2mg. Also planning to start Amisulpride 12.5mg daily in few weeks because why not.

Not really understanding your approach (just my opinion) I wouldn’t take amisulpride with aripiprazole there’s redundancy there and, most importantly, why target a specific aripiprazole dose ahead of time?

For me I didn’t feel anything for a couple weeks starting at 0.25 mg and until over a week on 0.5 mg. I’m almost at 4 months on Abilify and still taking around 0.6 mg and it still works just as well as when I plateaued at about 1 1/2 months in. I plan now on going to 0.75 mg but only after knowing how I felt for a long while on 0.5.

 

[Hipsman]

Not really understanding your approach (just my opinion) I wouldn’t take amisulpride with aripiprazole there’s redundancy there and

I just saw discussion that Amisulpride could reverse Abilify tolerance , so I thought it would increase my chances of abilify working long-term.

why target a specific aripiprazole dose ahead of time?

I just thought 2mg might give better results.

For me I didn’t feel anything for a couple weeks starting at 0.25 mg and until over a week on 0.5 mg. I’m almost at 4 months on Abilify and still taking around 0.6 mg and it still works just as well as when I plateaued at about 1 1/2 months in. I plan now on going to 0.75 mg but only after knowing how I felt for a long while on 0.5.

I just try to go through treatments like a speedrun basically, as long as it's "safe"

 

[leokitten]

I just saw discussion that Amisulpride could reverse Abilify tolerance , so I thought it would increase my chances of abilify working long-term.

That post shows ZERO explanation of how or why amisulpride would prevent Abilify tolerance, even though the person did "10 years of research" yet they cannot even spend a second to describe what is the mechanistic explanation? I cannot seem to find any reasonable mechanistic explanation as to why amisulpride would prevent Abilify tolerance?

 

[Martin aka paused||M.E.]

That post shows ZERO explanation of how or why amisulpride would prevent Abilify tolerance, even though the person did "10 years of research" yet they cannot even spend a second to describe what is the mechanistic explanation? I cannot seem to find any reasonable mechanistic explanation as to why amisulpride would prevent Abilify tolerance?

Do you have an explanation why Abilify works? Or read it in the studies?

 

[leokitten]

Do you have an explanation why Abilify works? Or read it in the studies?

Way more than a single anecdote of a person who doesn't have ME. Hundreds of anecdotes of pwME describing the same improvements.

 

[Hipsman]

That post shows ZERO explanation of how or why amisulpride would prevent Abilify tolerance, even though the person did "10 years of research" yet they cannot even spend a second to describe what is the mechanistic explanation?

it reversed his tolerance, so it isn't just a theory, no explanation is ok, I wouldn't explain it either since it was just a review and I don't think he expected anyone to take him seriously.

 

[leokitten]

Do you have an explanation why Abilify works? Or read it in the studies?

And I do have a plausible theory as to why Abilify works in ME based on available (scant) research of our understanding of ME and of aripiprazole.

ME is fundamentally cellular metabolism disorder causing dysregulation in the ability to generate ATP from energy sources in multiple cell types (or even all, but some are more sensitive to it than others). Therefore cell types cannot effectively meet their energy demands and fluctuations.

The dopamine system and dopamine neurons are well known to have a very high energy requirement, in fact I believe parts of the caudate nucleus have the highest energy demands of any part of the brain per volume. So the dopamine system is exquisitely sensitive to cellular metabolic dysfunction and thus cannot function properly, causing mulitiple neurological ME symptoms.

Dopamine-serotonin stabilizers (DSSs) like Abilify stabilize and bolster deficiencies in dopamine system function and neurotransmission. So basically picking up the slack caused fundamentally by ME energy metabolism disorder in dopamine and serotonin neurons or glial cells. It's actually pretty straightfoward.

 

[Martin aka paused||M.E.]

Way more than a single anecdote of a person who doesn't have ME. Hundreds of anecdotes of pwME describing the same improvements.

You are right ... This is an argument. But trust me - and I hope it will never occur -: if it stops working for you and you are very severe and can only communicate damaging your brain with benzos you desperately try many things. I will try other things first because of the same concerns you mentioned.