Abilify- Stanford Clinic Patients

[BananaMango99]

Dam, I should have tried to get the oral solution. I have exhausted my prescription getting the tablet. I wonder worth going back to the psych

 

[5vforest]

You could also crush and use a gram scale.

 

[BananaMango99]

You could also crush and use a gram scale.

Yes I have one, which is what I normally do. But the whole tablet weighs just 95 milligrams. At that weight my scale is probably +/-3mg error. So anything less than a tenth of that (9.5mg = 1mg Abilify), I think would be pushing it in terms of accuracy. I guess it depends how important accuracy is for dosing Abilify?

 

[mitoMAN]

Just dilute it in water and shake the solution gently to get it back into solution before you take it out with a syringe. That's how I did it

 

[BananaMango99]

Just dilute it in water and shake the solution gently to get it back into solution before you take it out with a syringe. That's how I did it

Thanks, I think that's my only option now as pharmacist told me there's no oral Abilify (maybe an Australian thing??) and my milligram scale doesn't pick anything up under 10-20mg.

Do you know how long the solution stays active? Or I guess it's probably just unlimited, where would it go

 

[percyval577]

I don't have any specific links about manganese.

I discovered manganese has mild antidepressant effects for me by accident, after trying this essential mineral.

Originally I took 40 mg daily, as that was the dose my Swanson manganese capsules provided, but found even if I took it in the morning, it would cause difficulty in getting to sleep. So then I reduced the dose, and found 3 mg in the morning still provides a mood boost without any insomnia issues.

Thanks.

That Mn may be involved in the precursery of dopamine is reported in Zhang et al 2010:
threads/manganese-nitric-oxide-in-the-nervous-system.78690/#post-2327242

 

[Hip]

Note that Abilify (aripiprazole) is eliminated from the body by two main liver enzymes, CYP2D6 and CYP3A4.

If you are taking any drugs or supplements which affect the efficiency of these liver enzymes, that will alter Abilify levels in the blood.

You can check which drugs or supplements affect these liver enzymes here:

Inhibitors and inducers of CYP2D6.

Inhibitors and inducers of CYP3A4.

For example, certain SSRI drugs like Prozac are potent inhibitors of CYP2D6.

 

[Hip]

@cogent_thought just pointed out in this post that selenium increases synaptic dopamine levels.

Years ago, I discovered that high-dose selenium substantially improves my ME/CFS. Thus this dopamine boosting property of selenium could explain why I found selenium so beneficial.


High dose selenium could be an interesting add-on for those experimenting with Abilify.

 

[BananaMango99]

Note that Abilify (aripiprazole) is eliminated from the body by through two main liver enzymes, CYP2D6 and CYP3A4.

If you are taking any drugs or supplements which affect the efficiency of these liver enzymes, that will alter Abilify levels in the blood.

You can check which drugs or supplements affect these liver enzymes here:

Inhibitors and inducers of CYP2D6.

Inhibitors and inducers of CYP3A4.

For example, certain SSRI drugs like Prozac are potent inhibitors of CYP2D6.

That's interesting as I'm on Prozac - does that mean prozac will increase Abilify's effects, or decrease?

Btw on your selenium high-dose - do you think 200mcg would do? Or would you really have to hit the 400?

 

[Hip]

That's interesting as I'm on Prozac - does that mean prozac will increase Abilify's effects, or decrease?

Btw on your selenium high-dose - do you think 200mcg would do? Or would you really have to hit the 400?

Prozac will lead to higher levels of Abilify in the blood from a given dose, so will increase the effects of Abilify.

With selenium, I found I only got strong effects when I took 400 mcg. But you could try 200 mcg.

 

[BananaMango99]

How about St John's Wort, that does something with dopamine doesn't it?

 

[Hipsman]

Anyone looked if there is a aripiprazole (abilify) derivative in research that has less side-effects?

I'm asking because we have found Sephin1, witch is a derivative of guanabenz with much less side-effects. So this is a possibility.

 

[leokitten]

Anyone looked if there is a aripiprazole (abilify) derivative in research that has less side-effects?

I'm asking because we have found Sephin1, witch is a derivative of guanabenz with much less side-effects. So this is a possibility.

Yes brilaroxazine, search the thread for more info. It beyond research it will likely be approved and avail for schizophrenia by 2024-2025

 

[leokitten]

A good summary document on brilaroxazine from an investment research firm looking at Reviva.

https://s1.q4cdn.com/460208960/files/News/2021/Zacks_SCR_Research_01132021_RVPH_Vandermosten.pdf

You can see the important improvements compared to aripiprazole, eg target receptor binding and affinities, virtually non existent off-target binding, much improved side effect profile (see bar charts summarizing results from phase II trial and comparing to aripiprazole 15 mg).

There’s also a decent summary table comparing all the existing antipsychotics at target receptors.

They are starting phase III trials (for schizophrenia) this year and looks like if everything is successful will be FDA approved in 2025. They are also in earlier trials stages for other indications and looks like it has potential for quite a number of indications.

They moved their brilaroxazine doc link and expanded their review thanks @jaybee00 for finding the new link

https://s27.q4cdn.com/906368049/files/News/2021/Zacks_SCR_Research_01132021_RVPH_Vandermosten.pdf

I’m attaching the file too in case it disappears again

 

[BananaMango99]

Third day of 0.125mg Abilify and I think this is too energising for me, unfortunately. Feels very similar to Moclobemide, which I also stopped for being too energising.

To illustrate, I usually start getting sleepy around 10-11pm. Both drugs seem to block that process, and actually even give a bit of a kick at that time, adrenaline type kick. Both then wake me up during the night once I do sleep. And both have rebound fatigue as a result of the over-energising

 

[Hip]

Third day of 0.125mg Abilify and I think this is too energising for me, unfortunately.

By "energizing", do you mean that Abilify is overstimulating? I found Abilify overstimulating, and could not relax with it.

But I found very low doses of a similar drug called amisulpride to be fine. Amisulpride has been shown to increase energy and reduce pain in ME/CFS in a small study. My thread on amisulpride here.

At 12.5 mg once daily, I found amisulpride substantially reduced my ME/CFS sound sensitivity (hyperacusis), and also dramatically reduced my irritability symptoms (irritability is listed as an ME/CFS symptom in some definitions of ME/CFS).

I did not get an increase in energy at this dose, but this might be because I am using too low a dose: the study actually used amisulpride 25 mg twice daily.

I did however notice a mood boost, an increase in sociability, and improvement in my ADHD.

 

[Yuno]

I find both Amisulpride and Abilify too stimulating unfortunately. If I take a drop of Abilify each day, I have a few good days, but have to stop after 5-6 days due to a heavy Migræne and rebound fatigue.
Amisulpride gives me a noticeable boost at 6mg, but unfortunately rebound fatigue the day after.
Looking forward to trialing sephin.

 

[Hoosierfans]

@Yuno and @BananaMango99 have you guys tried dosing every other day or every third day? There are some folks on theFB group that are doing that and seem to be better with the overstimulation. Overstimulation seems to be one of the most common side effects folks on the FBgroup are reporting (in the poll they use the word “agitation” or “restlessness” but f you read the comments it’s that folks are feeling amped up / overstimulated)

 

[Badpack]

@Hoosierfans the extreme half life length of Abilify doesnt make "days of" possible.

 

[Hoosierfans]

@Hoosierfans the extreme half life length of Abilify doesnt make "days of" possible.

Hmmmmm...well there are a couple of folks on the Abilify FB group who are doing it that way (every other day or every third day). My understanding was that it had a relatively long half life so that it was possible (even better) to do it that way (to prevent build up in your system which would cause low dose to work like high / normal dose Abilify). Maybe @mitoMAN or @Hip can clarify...