In my first 5 ot 6 years with ME/CFS, I had pretty bad mental health symptoms (appearing after the mild brain damage of the encephalitis which triggered my ME/CFS). These symptoms included depression, anhedonia, anxiety, mild psychosis and others.
I found that oxymatrine greatly worsened my depression, so was unable to take it, much as I wanted to try it. Only many years later, when I had improved a bit in health was I able to take oxymatrine without getting depression. But then unfortunately I found it did not help.
Ah ok but the many years later did you have any noticeable worsening or just no effect at all?