Among all retroviruses analyzed, XMRV has the strongest preference for transcription start sites, CpG islands, DNase-hypersensitive sites, and gene-dense regions; all are features frequently associated with structurally open transcription regulatory regions of a chromosome.
Integration Site Preference of Xenotropic Murine Leukemia Virus-Related Virus, a New Human Retrovirus Associated with Prostate Cancer
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Re: Huber failed XMRV.
From a Blog on the net.........
''It is also possible that XMRV may be able to induce transcription of an endogenous virus according to Brigette Huber,a professor of pathology at Tufts University’s Sackler School of Graduate Biomedical Sciences in Boston.She has been studying the presence of an ancient retrovirus,HERV-K18,which is dormant in most people but active in patients with CFS and multiple sclerosis.(29)Epstein Barr virus has already demonstarted that it can do this.(29,30)''
(29): Scientific American article,Retrovirus linked to chronic fatigue syndrom could aid diagnosis,available:
http://www.scientificamerican.com/article.cfm?id=chronic-fatigue-syndrome-retrovirus [accessed 30 Nov 2009]
(30): Francis C. Hsiao, Miao Lin, Albert Tai, Gang Chen and Brigitte T. Hube ‘ (2006)Cutting Edge: Epstein-Barr Virus Transactivates the HERV-K18 Superantigen by Docking to the Human Complement Receptor 2 (CD21) on Primary B Cells‘
http://www.jimmunol.org/cgi/content/abstract/177/4/2056 [accessed 30 Nov 2009]