I would love some help with interpreting my 23andme results. Here they are. There is much conflicting advice about what to do. Should I start with CBS? I read here that its CBS isn’t big deal so skip it? Or should I get sulphur and ammonia levels checked first? Where do I start? I really have no idea.
Your heterozygous CBS SNP doesn't affect gene functioning at all, so there's no reason to think there's any dysfunction based on these results.
Being heterozygous for COMT means you don't have the fast or slow versions for breaking down catecholamines, but are somewhere in the middle. With those being "normal" and the fast version of MAOA, they shouldn't be causing any problems with you tolerating methyl groups (methyfolate or methylB12).
VDR Taq being TT suggests that you're slow in producing catecholamines.
MTHFR C677T being AA means that you are very slow in producing methylfolate - going at about 30% of the normal rate. Hence supplementing methylfolate may be essential for you.
MTRR A66G results in higher homocysteine and lower methionine. B12 supplementation may help. If sensitive to methyl groups at all, hydroxoB12 should be a safer form than methylB12. If taking methylB12, be careful of potassium issues. MTRR A664A is irrelevant to gene functioning.
BHMT-08 has a minor impact on gene functioning, but that might not apply to the heterozygous version. The other BHMT SNPs are meaningless.
The AHCY SNPs are also meaningless.
SHMT1 can increase the malfunctioning of MTHFR C677T. This might only apply to AA, and not AG. In can indicate a need for folate and folinic acid.
SUMMARY:
Your MTHFR problem could be pretty severe. If you haven't had folate levels tested, it might be a good idea to do so. You almost certainly need to supplement methyfolate, and may need to avoid folic acid in the process (often added to breads, cereals, and other grains). You also might need some B12 and/or folinic acid.