endothelial dysfunction

Overview The endothelium, a single layer of epithelial cells, lines the inside of blood vessels and plays a crucial role in various processes such as blood flow control and clotting. Endothelial dysfunction, i.e. impaired function of the endothelium, has been demonstrated both in long COVID and...

Pre print Approved: 12 December 2023 Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) is a frequent, debilitating and still enigmatic disease. There is a broad overlap in the symptomatology of ME/CFS and the Post-COVID Syndrome (PCS). A fraction of the PCS patients develops the full...

Measurements and main results PCS patients exhibit persistent endothelial dysfunction (ED), as indicated by significantly lower venular flicker-induced dilation (vmax; 3.42% ± 1.77% vs. 4.64 % ± 2.59%; p = 0.02), narrower central retinal artery equivalent (CRAE; 178.1 [167.5 - 190.2] vs. 189.1...

Does anybody have any experiences with Sulodexide (Aterina) to address endothelial dysfunction, it’s sort of an oral version of heparin? (Of course this isn’t a cure, but possibly a drug to add on top of the usual stack). I've heard from his patients that Dr. Laubscher, who's the clinical...

Endothelial dysfunction in ME/CFS patients Sandvik MK, Sørland K, Leirgul E, Rekeland IG, Stavland CS, Mella O, Fluge Ø Objective: A few earlier studies have found impaired endothelial function in patients with Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS). The present study...

Abstract A proportion of COVID-19 reconvalescent patients develop post-COVID-19 syndrome (PCS) including a subgroup fulfilling diagnostic criteria of Myalgic encephalomyelitis/Chronic Fatigue Syndrome (PCS/CFS). Recently, endothelial dysfunction (ED) has been demonstrated in these patients, but...

Abstract Background: Fatigue, exertion intolerance and post-exertional malaise are among the most frequent symptoms of Post-COVID Syndrome (PCS), with a subset of patients fulfilling criteria for Myalgic...

Endothelial dysfunction and altered endothelial biomarkers in patients with post-COVID-19 syndrome and chronic fatigue syndrome (ME/CFS) Haffke et al, 2022 Authors: Milan Haffke, Helma Freitag, Gordon Rudolf, Martina Seifert, Wolfram Doehner, Nadja Scherbakov, Leif Hanitsch, Kirsten Wittke...

Letter: Could endothelial dysfunction and vascular damage contribute to pain, inflammation and post-exertional malaise in individuals with myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS)? By Jeffrey Lubell Link...

Decreased NO production in endothelial cells exposed to plasma from ME/CFS patients R Bertinat et al. Vascul Pharmacol. 2022. https://pubmed.ncbi.nlm.nih.gov/35074481/ Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a debilitating disease characterized by severe and persistent...

Persistence of SARS CoV-2 S1 Protein in CD16+ Monocytes in Post-Acute Sequelae of COVID-19 (PASC) up to 15 Months Post-Infection (Patterson et al., 2022) https://doi.org/10.3389/fimmu.2021.746021 A publication by Bruce Patterson and colleagues, regarding findings in the blood from Long Covid...

:star:The more you know!:star: So, the parasympathetic branch of the autonomic nervous system is responsible for producing a penile erection (or vaginal lubrication) in response to stimulation. This means that if there is a problem with this part of the autonomic nervous system, one might...

We all know the poor man's tilt table test, but is there an equivalent for endothelial function? The most usual way to measure endothelial function is via the Flow Mediated Dilation (FMD) test. It is not a high-tech test, but it tends not to be easily available either (not sure why). I am...

An attempt to explain the neurological symptoms of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome Klaus J. Wirth, Carmen Scheibenbogen and Friedemann Paul Link Full text link Abstract There is accumulating evidence of endothelial dysfunction, muscle and cerebral hypoperfusion in Myalgic...

Authors: Fogarty et al Published: 10th Aug 2021 DOI: 10.1111/jth.15490 Full Text: J Thromb Haemostat (open access PDF) ABSTRACT ESSENTIALS Ongoing endotheliopathy is a common finding in convalescent COVID-19 patients and is independent of the acute phase response. Plasma FVIII:C levels and...

Since they finally seem to have their first paper published soon, this time for real, hopefully, I'd like to discuss this latest update. Their main point for the symptomology is angiogenesis and vasodilation. This also happens in MCAS and CFS/ME, though. This is why histamine-induced symptoms...

I thought I'd start a thread to summarize discussions about the different types of endothelial dysfunction that might be found in ME. Please feel free to add to this thread as needed. What is "Endothelial Dysfunction"? Blood vessels are enclosed by a layer of cells called endothelial cells...