I decided to give methylation one more whack since nothing has ever worked. I used to have really bad hyper reactions to mb12 but since revisiting it I'm doing fine with mb12 The only difference now is i have been treating a gut infection of prevotella with high dose bile and my derealization/depersonalization doesn't flare as badly when i eat. I know the biproduct of prevotella is hydrogen sulfide so im not sure if that is detoxed through the methylation pathway or not. Anyway, im now at 15 mg mb12 taken sublingualy every day with no issues. Where should i go from here? Time to start taking mfolate? I've taken high doses of it in the past with no effect so i feel i don't need to start too slowly. I did a methylation profile a while back and it came back pretty normal. Im not sure how much emphasis you guys put on this? I can also take obscene doses of ALA and SAMe with no effect. Thanks for any advice here.