Hi Not sure how familiar people are with QuickSilver's products but I started taking IMD a couple of weeks ago. I am not doing their full protocol which includes taking 50mg+ of liposomal r lipoic acid per day as I want to remove as much Mercury from my gut as possible before beginning to mobilise it from deeper tissues and my brain. My hypothesis here is that whenever I have taken anti microbials previously I have suffered massively with "die off". In realtity I believe that a significant part of what I have in the past referred to as "die off" was in fact heavy metals being liberated from dying gut microbes and redistributed. This time I am using IMD in conjunction with my anti microbial and biofilm disruption protocol in order to prevent significant metal related symptoms. My question here is that QuickSilver recommend that their products be used in cycles of 5 days on/2 days off and later 10 days on/4 days off. This seems to be based however on their full protocol which includes amongst other things r lipoic which is a potent mobiliser of mercury from the brain and tissues. So for this reason I fully understand the need for breaks. I am not taking r lipoic however so I wonder do I need to take breaks from IMD or can I take it consistently? After all it could be argued that an aggressive antimicrobial protocol without IMD everyday could be harder on the body than taking breaks as on the break days there is no metal binder in the gut. Any thoughts ? I have read as much as I could find on IMD and watched a few presentations by dr Christopher shade on YouTube. What I keep hearing about IMD is that it does not enter systemic circulation, interrupts enterohepatic recirculation of Mercury and does not result in any Mercury re-distribution symptoms. On that basis I am arguing (with myself!) that I am doing less harm taking it every day than taking breaks. That said however I don't want to crash and burn or make myself worse in any way. My head is clearer since starting to take it and my digestion has improved but my sleep is worse and I am quite lethargic. Of course this could be caused by a multitude of factors. I am taking supplemental minerals every day away from IMD. I contacted quicksilver scientific directly and spoke with their representative who predictably stated they could not advise me and that in most cases patients are on the full protocol which includes r lipoic and other items. Would he greatful to hear any views from people who are familiar with this product. Thanks a lot.