SOC
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I don't know what immune modulators would be likely to throw off a lymphocyte subset panel. I take Valcyte, which reportedly has immune modulating effects. I know some of the supplements I take are reported to have an effect on NK cells (number or function, I'm not sure).What are you taking right now? Is there any possibility that you're taking immune modulators that could be throwing off the lymphocyte subset panel?
Have you and your daughter done 23andme at all, or any other type of genetic study?
SPEP is a good test to do and imo indicated when there are strange results on lymphocyte panels coupled with Ig deficiencies. Hopefully (and probably) it will be normal which is one less thing to worry about.
Chest x-ray is also useful if you are concerned about Hodgkin's Lymphoma - but that is based on your family history rather than any specific abnormalities in the testing you just listed for me.
When is your appt with the hematologist?
Have you had bad reactions to any vaccines in the past?
Daughter and I both did 23andme and didn't see any results that would suggest a well-known genetic immune disorder.
I'm not particularly worried about Hodgkin's Lymphoma. It's more a matter of being a little more alert to immune abnormalities. With at least three cases of Hodgkin's Lymphoma, at least three cases of ME/CFS, and one very severe case of poliomyelitis in the past three generations, there's reason to suspect a genetic weakness in our ability to control viruses. No big worries, just reason to pay attention.
My appointment with the hematologist is Monday. I see Dr Klimas at INIM 10 days later. I should have a lot more data in 2-4 weeks.
I don't typically have bad reactions to vaccines. I get the killed, preservative-free flu shot every year with no problems. IIRC, the last time I had the PneumoVax (about 5 years ago), I felt more than usually crummy for longer than is usual for a vaccine, but it was nothing serious.
My daughter's ME got much, much worse after a bunch of pre-college boosters all on the same day, including a live VZV booster. That's the only time either of us had a problem with vaccines.