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Both slow and fast liver phase 1 possible?

Discussion in 'Detox: Methylation; B12; Glutathione; Chelation' started by jason30, Nov 20, 2015.

  1. jason30

    jason30 Senior Member

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    Hi all,

    I am having problems with detoxing and I am trying to determine what my liver phase 1 and 2 status are.

    I have Multiple Chemical Sensitivities, what means that I have a fast phase 1 and slow phase 2, says the theory.
    However, I am also sensitive to caffeine, slow caffeine clearance, which is a direct symptom of a slow phase 1.

    In order to threat my liver problems I try to figure out if I have a slow or fast phase 1. Does anybody know if there can be both (unlikely though!) ? Or have more information about determine the status of phase 1 and 2 of the liver?

    Thanks in advance for any help on this subject!
     
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  2. Gingergrrl

    Gingergrrl Senior Member

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    @jason30 I am of no help but am very curious on this topic and bumping up the post hoping someone else responds. I am also (now) intolerant of caffeine and have slow liver detox which affects the dosages and amounts of meds that I take. But am still an amateur at understanding this and how to work with it!
     
  3. Little Bluestem

    Little Bluestem All Good Things Must Come to an End

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    I have no knowledge on the subject, but am wondering if you could have a phase 1 slow enough to cause slow caffeine clearance and an even slower phase 2 to cause multiple chemical sensitivities.
     
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  4. sregan

    sregan Senior Member

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    Grapefruit is supposed to slow down phase 1 detox (see link)
     
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  5. Helen

    Helen Senior Member

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    Does it? That would be interesting to read more about. Do you have a source.

    Different CYP´s or SNP´s mean upregulation OR downregulation according to how they act on enzyme production. I can´t see how the sum of enzyme production from CYP´s in Phase I could be both slow and fast at the same time. Maybe certain food, or substances , could up- or downregulate certain CYP´s as much as to change from fast to slow or reverse for the total Phase I detoxification.
     
  6. jason30

    jason30 Senior Member

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    In the past 2 years that's the only thing I have read about it; a fast phase 1 and slow phase 2 indicating MCS. Though all sources doesn't have any references to researches.

    2 sources:

     
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  7. jason30

    jason30 Senior Member

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    Good to know, thanks!
     
  8. jason30

    jason30 Senior Member

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    I don't know if that's possible, but in theory it could be the case by me as well!

    Soon I will start with foods and supplements that inhibit phase 1 and stimulate phase 2. I'm very curious how I will react.
     
  9. Gondwanaland

    Gondwanaland Senior Member

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    For a long time I thought I had fast phase I and slow phase II, and slowing down phase I was the worst thing I ever went thru (I used Nicotinamide, Boswellia).
     
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  10. jason30

    jason30 Senior Member

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    I wonder, what did you felt when you took nicotinamide in terms of slowing down phase 1?
     
  11. Gondwanaland

    Gondwanaland Senior Member

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    A feeling of liver congestion and worsened intolerance to smells. Niacin didn't cause that. Magnesium relieved it.
     
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  12. jason30

    jason30 Senior Member

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    Thanks!
    I asked because I experience the same thing.
    Same as you, both Niacinamide and Boswellia worsened the situation in terms of MCS/liver issues.
    But on the other hand, after intake of niacinamide I suddenly smell the original smells in the car. That was a long time ago and is for me a positive thing.
    So my guess is that niacinamide does do some good things for my MCS, but at the same time it decreases important liver enzymes who are associated in phase 1 and which makes an other liver situation more worse.

    If I recall correctly, you are using magnesium oxide for that?
     
  13. Gondwanaland

    Gondwanaland Senior Member

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    Indeed
    I stopped tolerating it. Now I tolerate Mg Aspartate.
     
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