well, I think I'll create a thread on how it goes. I'll put my questions here too ( hope for feedback from more exprienced members, there is an awful lot of information out here, a bit overwhelming really)I've to jot it down anyway and this place seems to be the place for it. I started end november with half a mg metcob and half a mg adcob as a spray, result was that half an hour later a curtain opened up in my head, huray I thought, I'm on the right track. Then I bought and read Myhills book, she advises 5mg metcob a day ( or half a mg metcob as injection) so I started to build up the dose. I had old problems ( especially worsened sleep and pain in the joints) coming back. But the head kept clearing up mightily) so I went on. New problem was ( and is) pain in the backside of my legs, starting back of the knees and going out both up but especially downwards)Then I PEMcrashed due to cognitive overload ( or maybe from too much metcob in too short a time). I reduced the amount of metcob from 3 to 2mg. And recuperated, sleep became better, still not enough but restorative, wow! Then started reading Fredds take on things and added adcob. ( I had already bought that, It felt so logical to mee somehow, to take both sorts) also bought Potassium and needed it, Thanks @Freddd Now it's half February. I did not up the dose yet, sleep is being much better, still wake up in the middle of the night. But most nights I sleep about 7 hours ( with an hour break in the middle). And I wake up refreshed, this feels amazing, I haven't slept that long and well in years now. And I fall asleep much faster, i was used to laying still at least an hour, now many nights I just fall asleep in less then half an hour, really amazing! Further I seem to have a little more energy, after months of being totally housebound, I've been out for a small walk ( few minutes) twice this week, feels good. Muscletension that I had in check with some supplements is now so low that I sometimes forget my sups. I've reduced the amount of 5HTP that I use before going to bed Now I'm slowly adding some supplements, next to the codliveroil and linseedil I already took, I now take a fishoilcap and hempoil. I want to add primrose oil too. I stopped my Bcomplex ( reason later) and am slowly creating my own combination of B's I added K again, because I stopped drinking goatsmilk (so adding K again is dangerfree.) ( I've tightened up my dietary regime) Now I need to add calcium , I tried that earlier but i did not do well on it, so I'll have to be careful feeling what it does to my body. and the zinc, Two years ago I had a total and very bad crash on it. But... by now things should have changed, so I will try it, starting with 2mg. further boron, manganese, molybdenium and chrome. when I've added all these I'll will start to take more B12 Then GP did some bloodwork on me. Thyroid is going too fast, he's now testing on TSI ( happy he's testing but I am scared a bit, I hope it's something else) B1 and B6 were waaay too high. so I stopped Bcomplex, B1- need for potassium instantly diminished to zero B6- it was the easy to take form P5P, why does my body not use the stuff? is that part of the methylation too? last time he did bloodwork folic acid too was too high, now I suppose that with taking B12, this will balance out soon and then I'll take folate again. I did use B11 as L-5-Methyltetrahydrofolate from L-5-Methyltetrahydrofolic Acid, Glucosamine Salt and have now bought Folate (from Quatrefolic, (6S)- 5- Methyltetrahydrofolic acid, glucosamine salt] so I'll ask GP if he will regularly test blood for pholic acid/B1/B6 anymore?? regarding the methylation? and now the surprising thing, when glucose is tested, I always had low scores, 4.3 or 4.2. Now it was 7.9 which is a little too high and absolutely baffles me. what the heck is happening in my body and what can/will using B12 change in all these things?? I feel decidedly better with the B12, but bloodwork shows things that I'm not happy with. why the heck has nobody ever told me I should take B12, now that the brainfog is lessened, I see that it is the first thing my former GP should have advised 5 years ago... that feels real bad, needless suffering and maybe needless unfixable damage, stupid doctors!!