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Autoantibodies and ANAs

Discussion in 'Autonomic, Cardiovascular, and Respiratory' started by Malea, May 13, 2018.

  1. Malea

    Malea

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    I have to tell my (family) doctor tommorrow about the autoantibodies I tested positive for. (Adrenergic, muscarinic ACh and angiotensin)
    At the same time I have negative ANAs (1:80) and I worry that my doctor will think that there can‘t be a problem because of the negative ANAs. (That is what a rheumatologist told me a few weeks ago)

    Does anybody know why the ANAs can stay negative even though there may be a lot of autoantibodies?
     
    Lisa108 and outdamnspot like this.
  2. Lisa108

    Lisa108 Senior Member

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    As I understand it, ANAs are a totally different type of autoantibodies. So the ones you tested positive for couldn't show up in a test for ANA (and vice versa).

    The ANA test is not a general unspecific test to see whether you have autoantibodies (or not). It is specific and searches for "autoantibodies-that-bind-to-proteins/protein-complexes-in-the-cell-nucleus".

    The autoantibodies you tested positive for are targeted against receptors.

    So the rheumatologist could only rule out diseases that are associated with ANAs (Lupus, Sjögren's,...). But there are lots of other diseases that are associated with different (not ANA) autoantibodies.
     
    sb4 and Malea like this.
  3. Malea

    Malea

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    Thanks a lot, @Lisa108. That makes total sense!

    And I assume a general unspecific test that would also detect autoantibodies against receptors might not exist?
     
  4. Lisa108

    Lisa108 Senior Member

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    Not to my knowledge. Maybe others here know better...
     
    Malea likes this.

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