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23andme results no MTHFR mutations (Help)

Discussion in 'Detox: Methylation; B12; Glutathione; Chelation' started by uriraha8, Jul 4, 2014.

  1. uriraha8


    I have finally done the 23andme test.

    This quite surprised me cause i was sure i had some mthfr issues but i don't.
    I suffer from chronic fatigue and depression which antidepressants do nothing for it.

    I found out i have some mtr/mtrr issues which as i read this mutation needs lots of methyl B12 which i already taking 1 mg daily.

    Should i add methyl folate for it? although i don't have any mthfr mutation? Cause i feel a bit anxious when taking the methyl B12 alone.

    I also have comt mutations should it be a problem? I understand people with comt mutations can't tolerate methyl groups very well.

    Is there anything i can do with the VDR/Taq mutation? i have vitamin d deficiency but i can't tolerate high doses of vitamin d (it cause me migraine) i can only tolerate 1000IU daily.
    Should i continue with the methyl B12 and methyl folate? or exchange it to hydroxy B12 base on my results.

    Any help will do for me i really need it


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    Last edited by a moderator: Jul 4, 2014
  2. UM MAN

    UM MAN Senior Member

    VDR Taq AA is not a mutation, it is normal.

    There are a lot of MAO-A homo-z people on here with depression and anxiety issues,
    but, so far there does not seem to be reified treatment.
    ramkishore likes this.
  3. Valentijn

    Valentijn Senior Member

    @uriraha - I don't see any problems in those results. If you want to look at additional MTRR and MTHFR mutations which might have an impact, there's lists at and

    Additionally, there's a downloadable program at which pulls out your very rare results. SNPs starting with "i" instead of "rs", and homozygous results can be especially interesting.

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