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This article explains methylation in very simple language. Keep in mind, when the author mentions "folic acid" he is referring to folinic acid and methylfolate rather than the folic acid you see in most supplements. Good luck.i am very much hoping someone will be kind enough to help me understand the metbylation process/blockage
in as few words as possible.
I suggest that another mechanism that could give rise to excitotoxicity on this type of treatment is that when the methylation cycle partial block is lifted, the detoxication system begins to operate better, since it depends to a large degree on sulfur-containing substances, and the methylation cycle controls the overall sulfur metabolism. When the detoxication system's function begins to improve, it can be expected that lipid-soluble toxins that have been stored in the body will be mobilized into the blood before they can be excreted into the urine and bile by the kidneys and liver, respectively. Those that are able to cross the blood-brain barrier may then be able to stimulate the NMDA receptors during the time when their levels in the blood are elevated. I think this would be another possible mechanism that could give rise to excitotoxicity on this treatment.
lotus97
perfect thanks. i have started to understand it a bit.
http://www.hdri-usa.com/tests/methylation/
this is the lab mentioned in the article. i was wondering if they deal with the UK.
Rich has suggested getting the test, but like I said it's pretty expensive. I don't know if it's necessary or not. You can check out this thread about it. Maybe you can post in that thread to see if anyone else has had success with it.thankyou.
in the simplified article it states 'the average starting value of glutathione in our patients was 3.2 mmol/L (normal 3.9 - 5.5 mmol/L)
as i noticed dr myhills range is much lower.
if rich thought it was important to get tested first - even though i wasnt on the forum then - his posts do have a trustworthy feel to them even though i cant understand a lot.
i will email the USA office first then if netgerlands are difficult to communicate with.
Some of this stuff is partially of a theoretical nature, but from what I understand it's more than just glutathione depletion although that might be a big part of it.Is it fundamentally a glutathione deficiency then? which prevents lymphatic drainage - which encourages virus/bacteria which further depletes glutathione?
Just remember that it has methylfolate and folinic acid so you don't need to take those separately. You might want to just start out on B12 and then slowly work your way up to 6 capsules of the multi starting with just one a day.the childrens vitamins sound like a good solution for me - thankyou.
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i will email the USA office first then if netgerlands are difficult to communicate with.
Unfortunately the US office is difficult to communicate with too! And they send all the blood samples to the Netherlands anyway. Shipping is going to be the most complicated issue to deal with here, so you might as well just work with the Netherlands office.
Best wishes,
Sushi
i must say i have exchanged a couple of emails with the usa office today and they were prompt and efficient in their replies.
but maybe it was just very good timing and this is unusual.
the most difficult thing for me would be finding a doctor who will order them.
still wondering what to do about this. is there anywhere you can just pay for the tests direct without having to ask the permission of a doctor?
i must say i have exchanged a couple of emails with the usa office today and they were prompt and efficient in their replies.
but maybe it was just very good timing and this is unusual.
the most difficult thing for me would be finding a doctor who will order them.
still wondering what to do about this. is there anywhere you can just pay for the tests direct without having to ask the permission of a doctor?
I'm glad they were responsive. I haven't interacted with them for a couple of years so they must be easier to deal with now. The test is good though, no matter what the road-bumps along the way.
I remember that someone posted of a way to get this test without a doctor's prescription, but I can't find it now.
Maybe someone else will remember. I think it was a US connection though. A chiropractor can also prescribe the test if that is any easier.
Best,
Sush
I've also had a good experience with the US office. They always answer my emails very quickly.
Golden, Dr. Ben Lynch offers the methylation panel on his website, but it's more expensive compared to going through a practitioner. He charges $395, whereas it normally costs $295.
I have to say that I'm so glad I did the panel. I just received my results over the weekend, and they confirm that I have a methylation issue. After years of countless lab tests, I finally have an indicator that can explain the severity of my condition.
I just received my results over the weekend, and they confirm that I have a methylation issue.
My experiences with the US office have been less than stellar, especially with regards to the Nagalse test I did late last year.
When was your blood drawn for the methylation testing? I'm now waiting for those results, had blood drawn 4 weeks ago.
thanks lotus97,
It was when i came into close contact with someone diagnosed M.E. that i became very ill although it would be over a decade later the diagnoses was given.
I dont know whether this would be considered a cluster case and so render the methylation testing irrelevant.