Really good points, Sushi. (my bolds) I have been really concerned about Freddd puttting himself exclusively "in charge" of the methylation threads. In my personal experience, his protocol is extreme, and his style of working with people does not account for individual differences or individual LIMITS, something that Rich was very very careful to consider. I had *SEVERE* detoxification symptoms (heart palpitations, dizziness, and shortness of breath, that immobilized me completely) after just 10 days on Freddd's active B12 protocol. Freddd predictably dismissed and reduced my symptoms to a "START-UP REACTION." In time, I saw him do this regularly to other people as well. In fact, START-UP REACTION and INDUCED PARADOXICAL FOLATE DEFICIENCY were his standard responses for almost every problem someone had on his protocol. And yeah, the hypokalemia was thrown in there in good time as well. As for DETOXIFICATION symptoms, in my case Freddd argued, rather prolifically, that I couldn't possibly be having a detox reaction. It was start-up, start-up, start-up (in so MANY words). Fortunately I was able to procure a fecal metals test at the peak of my crisis. Sure enough, the results showed that I had been detoxing several toxic heavy metals, which had been mobilized while taking the methyl and ad B12, in doses that I now know were much too high for me. Rather than encourage me to slow down the pace of methylation, and lower my doses, in order to minimize the severity of my reactions, FReddd encouraged me to UP my doses and push through. That was the point where I stopped his protocol completely and focused on Rich's protocol instead. My body is too fragile and my nervous system is much too sensitive, to blast it into crisis with high dose methylation supps. I hope people take what Freddd says with a very BIG grain of salt. He is not a medical health professional, and according to my understanding of th forum rules, he should not be prescribing treatments and doling out medical advice on this forum. Given his track record with pushing his agenda and pushing high doses, I think a high deal of caution is warranted here.