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quercetin, yes -- but adding bromelain?? probably no

Sherlock

Boswellia for lungs and MC stabllizing
Messages
1,287
Location
k8518704 USA
Quercetin is said to have problems with absorption. As a result, it is sometimes sold combined with bromelain, which comes from pineapple, to increase absorption. Quercetin is also said to increase absorption of drugs like penicillin.

However, the MOA is that (as being composed of one or more proteases), bromelain likely increases gut permeability, which seems like a bad idea for people here.

Also, here's a study with heparin:
"Improvement of the intestinal membrane permeability of low molecular weight heparin by complexation with stem bromelain."
2006 http://www.ncbi.nlm.nih.gov/pubmed/16950580

which gets more complicated because intestinal mast cells do contain heparin

- and btw medical heparin is derived from animal intestines (and lungs).
 

Dreambirdie

work in progress
Messages
5,569
Location
N. California
interesting. Thanks.

I take a high potency quercitin called ISOQUERCITIN, that I get from my naturopath's office. It has no bromelain like the commercial brands I have taken. It's made by Integrative Therapeutics Inc.
 

Little Bluestem

All Good Things Must Come to an End
Messages
4,930
I used to take quercitin and bromelain for allergies. When I read that quercitin can interfere with liver function, I switched to bromelain and tumeric. I guess I will have to find something else.
 

Sherlock

Boswellia for lungs and MC stabllizing
Messages
1,287
Location
k8518704 USA
When I read that quercitin can interfere with liver function
Hi, Bluestem. Are you referring to how quercetin interferes with breaking down pharmaceuticals? I put a list just today here: http://forums.phoenixrising.me/index.php?threads/quercetin-is-a-bioenhancer.19221/

Here's a much longer list from webmd:
http://www.webmd.com/vitamins-suppl...gredientId=294&activeIngredientName=QUERCETIN

Elsewhere, I'd seen that an FDA approved formulation of some drug with quercetin resulted in using only 60% of the amount of drug that had been previously alone - so it's not necessarily a bad thing as long as it's properly accounted for.


But aside from that, I see that quercetin can be very helpful to the liver in conditions like cirrhosis or fatty liver disease. Ah well, so many supplements claim to be great for so many things - but at least claiming a benefit is better than having to point out a known danger :)
 

Little Bluestem

All Good Things Must Come to an End
Messages
4,930
I read that quercetin might slow down phase I detox. I think I also read that some PWME have phase I running faster than phase II, so that might not be a bad thing in some instances.
 

carolwxyz99

Senior Member
Messages
114
I read that quercetin might slow down phase I detox. I think I also read that some PWME have phase I running faster than phase II, so that might not be a bad thing in some instances.

I take quercetin as I was advised to take it for breast cancer prevention, as it came up positive in a research in-vitro test against my cancer cells. Do you happen to have a link to where you read that quercetin may slow down phase I detox? Thanks.
 

adreno

PR activist
Messages
4,841
Quercetin is also a phytoestrogen, which might not be so good for males.
 

Rolo

Too ill to twist
Messages
29
Location
Antwerp, Belgium
However, the MOA is that (as being composed of one or more proteases), bromelain likely increases gut permeability, which seems like a bad idea for people here.

Also, here's a study with heparin:
"Improvement of the intestinal membrane permeability of low molecular weight heparin by complexation with stem bromelain."
2006 http://www.ncbi.nlm.nih.gov/pubmed/16950580

.

Hi Sherlock,

Your conclusion confuses me. I thought bromelain was just healing the gut lining. I'm far from a medical specialist but I would think that they mean something else with "Improvement of the intestinal membrane permeability" . Namely an improvement of the normal uptake through the membrane the epithelial cells and NOT between the cells.

Especially the conclusion ath the end "This study provides evidence that heparin and bromelain form stable complexes leading to a significantly improved uptake of heparin" let me think that this has nothing to do with "leaky gut"

Could somebody confirm or deny my assumption.

Thanks, Rolo
 

Lotus97

Senior Member
Messages
2,041
Location
United States
What about taking bromelain with food as a digestive enzyme? Would that be as damaging as taking bromelain on an empty stomach like many people do (either with or without quercetin)? I decided I'm going to stop bioperine due to its affect on gut permeability. I might stop bromelain too. I hate to waste supplements though...

Also, why is recommended to take vitamin C with quercetin?

And someone started a thread on quercetin's effect on mitochondria and fatigue
http://forums.phoenixrising.me/inde...ect-on-mitochondial-production-fatigue.22356/
 
Messages
2,565
Location
US
I was taking Q and B together, but they give me a fever. I suspect that Q alone would too.

I also read you should take breaks from them. Taking them continously is bad for some reason.