PhoenixBurger
Senior Member
- Messages
- 202
"Quercetin is one of a broad group of natural polyphenolic flavonoid substances that are being investigated for their widespread health benefits. These benefits have generally been ascribed to its combination of antioxidant and anti-inflammatory activity, but recent in vitro evidence suggests that increased mitochondrial biogenesis could play an important role. However, the effects of quercetin on mitochondrial biogenesis and exercise tolerance are unknown. This study examined the effects of short-term quercetin feedings on markers of mitochondrial biogenesis, including expression of PGC-1α and SIRT1, mtDNA and cytochrome c concentration in both skeletal muscle and brain. The data indicate that short-term feedings of the dietary flavonoid quercetin can increase mRNA expression of PGC-1α and SIRT1, and mtDNA and cytochrome c in both skeletal muscle and brain. Furthermore, we determined if these changes in mitochondrial biogenesis were associated with an increase in maximal endurance capacity and voluntary wheel-running activity; both were increased following 7 days of quercetin feedings."
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Quercetin is probably the only supplement that gives me near 100% relief of my symptoms. I struggle with significant exercise intolerance. Muscle twitching all over my body. Fibromyalgia like pains. Nerve pains. And sensory problems. All heavily associated with systemwide Lack of proper energy production. Possibly qualifying as mitochondrial dysfunction.
This study goes into great detail analyzing Quercetins ability to generate new, healthy mitochondria in central nervous system and peripheral tissues. Including the brain. Which should play a central role in preventing neurodegenerative disease. Something that has never been analyzed before with Quercetin, I don't think. Additionally, they check for its effect on exercise tolerance, and systemwide mitochondrial efficiency which heavily affects fatigue.
In my case, a hyperactive immune system, with inflammatory hyperexcitability of nerves and muscles results in my symptoms. Quercetin for some reason completely calms all of this for me. Rather than jumping on it and enjoying the symptom relief however, I started doing some research to see exactly what it does in the body. And ran across this study. I think it may be relevant to many here. Worth a full read.
http://ajpregu.physiology.org/content/296/4/R1071.long
"Although often ignored, the brain also plays a primary role in exercise tolerance. Cerebral metabolism has important consequences on motivation, mood (e.g., vigor, fatigue, anxiety, depression), and central motor drive from the cortex (20, 27, 31), and increased brain mitochondrial activity could certainly enhance cerebral metabolism. PGC-1α expression is linked to the demand for mitochondrial ATP production and intracellular calcium levels (12, 25), both of which are known to increase under physiologically demanding conditions such as exercise and energy deprivation (12). PGC-1α activates mitochondrial biogenesis and increases oxidative phosphorylation by facilitating transcription, translation, and replication (22). As a result, peak oxygen uptake increases and fatigue is delayed during prolonged exercise (4). SIRT1 functions together with PGC-1α to promote mitochondrial biogenesis (24); SIRT1 interacts with and deacetylates PGC-1α at multiple lysine sites, increasing PGC-1α activity. This information has led to great interest in developing drugs to target the SIRT1-PGC-1α coactivator complex or related signaling pathways in the muscle that would mimic or potentiate the effects of exercise to treat metabolic diseases (17, 24). However, there have been no studies that focus on this effect in the brain. Our data indicate that PGC-1α and SIRT1 expression are increased significantly in both skeletal muscle and brain following just 7 days of quercetin feedings. We did not measure protein concentration of PGC-1α or SIRT1; however, changes in mRNA of these factors generally reflect changes in protein and activity (13)."
PB
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Quercetin is probably the only supplement that gives me near 100% relief of my symptoms. I struggle with significant exercise intolerance. Muscle twitching all over my body. Fibromyalgia like pains. Nerve pains. And sensory problems. All heavily associated with systemwide Lack of proper energy production. Possibly qualifying as mitochondrial dysfunction.
This study goes into great detail analyzing Quercetins ability to generate new, healthy mitochondria in central nervous system and peripheral tissues. Including the brain. Which should play a central role in preventing neurodegenerative disease. Something that has never been analyzed before with Quercetin, I don't think. Additionally, they check for its effect on exercise tolerance, and systemwide mitochondrial efficiency which heavily affects fatigue.
In my case, a hyperactive immune system, with inflammatory hyperexcitability of nerves and muscles results in my symptoms. Quercetin for some reason completely calms all of this for me. Rather than jumping on it and enjoying the symptom relief however, I started doing some research to see exactly what it does in the body. And ran across this study. I think it may be relevant to many here. Worth a full read.
http://ajpregu.physiology.org/content/296/4/R1071.long
"Although often ignored, the brain also plays a primary role in exercise tolerance. Cerebral metabolism has important consequences on motivation, mood (e.g., vigor, fatigue, anxiety, depression), and central motor drive from the cortex (20, 27, 31), and increased brain mitochondrial activity could certainly enhance cerebral metabolism. PGC-1α expression is linked to the demand for mitochondrial ATP production and intracellular calcium levels (12, 25), both of which are known to increase under physiologically demanding conditions such as exercise and energy deprivation (12). PGC-1α activates mitochondrial biogenesis and increases oxidative phosphorylation by facilitating transcription, translation, and replication (22). As a result, peak oxygen uptake increases and fatigue is delayed during prolonged exercise (4). SIRT1 functions together with PGC-1α to promote mitochondrial biogenesis (24); SIRT1 interacts with and deacetylates PGC-1α at multiple lysine sites, increasing PGC-1α activity. This information has led to great interest in developing drugs to target the SIRT1-PGC-1α coactivator complex or related signaling pathways in the muscle that would mimic or potentiate the effects of exercise to treat metabolic diseases (17, 24). However, there have been no studies that focus on this effect in the brain. Our data indicate that PGC-1α and SIRT1 expression are increased significantly in both skeletal muscle and brain following just 7 days of quercetin feedings. We did not measure protein concentration of PGC-1α or SIRT1; however, changes in mRNA of these factors generally reflect changes in protein and activity (13)."
PB