Sushi
Moderation Resource Albuquerque
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I just read an article about orexin and sleep. It seems that orexin (a neurotransmitter, I believe) supports wakefulness and that orexin inhibitors or antagonists, allow the brain to let go and sleep. Pharmaceutical companies are developing sleep meds using this pathway: http://www.news-medical.net/news/20120726/Insomnia-an-interview-with-Dr-Darryle-Schoepp.aspx
So, I'm wondering about natural ways to inhibit orexin or block its receptors. Here is one article I found: http://en.wikipedia.org/wiki/Orexin
To quote from it:
Does anyone with knowledge of biochemistry have ideas about how we might use this pathway (hopefully through food or supplements) to help us with sleep?
Best sleep wishes!
Sushi
So, I'm wondering about natural ways to inhibit orexin or block its receptors. Here is one article I found: http://en.wikipedia.org/wiki/Orexin
To quote from it:
Orexin increases the craving for food, and correlates with the function of the substances that promote its production.
Leptin is a hormone produced by fat cells and acts as a long-term internal measure of energy state. Ghrelin is a short-term factor secreted by the stomach just before an expected meal, and strongly promotes food intake.
Orexin-producing cells have recently been shown to be inhibited by leptin (through the leptin receptor pathway), but are activated by ghrelin and hypoglycemia (glucose inhibits orexin production). Orexin, as of 2007, is claimed to be a very important link between metabolism and sleep regulation.[citation needed] Such a relationship has been long suspected, based on the observation that long-term sleep deprivation in rodents dramatically increases food intake and energy metabolism,...
Does anyone with knowledge of biochemistry have ideas about how we might use this pathway (hopefully through food or supplements) to help us with sleep?
Best sleep wishes!
Sushi