Learner1
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I'm newer here and poked around to see if this was discussed anywhere else and didn't see it, so I'm hoping this is the right place to post this....
Does B6 matter?
I've had high serum ferritin for over a year. My doctor thinks it's due to my chronic infections, but ran an iron study to be sure. The results I had indicated either hemochromatosis or B6 deficiency anemia. I'm compound heterozygous for the 2 common HFE mutations, but my doctor said most people he'd seen with it had serum ferritin over 1000, which mine wasn't.
Hematocrit, MCHC, and sed rate had dropped, which seem to be related - looked like B6 deficiency was impacting heme metabolism, so hemoglobin wasn't picking up iron to be able to carry oxygen around in my red blood cells, which were misshapen.
We decided to up my P5P dose to 400mg, and sure enough my iron numbers are normalizing... BUT...
I reviewed my lab results for the past 5 years, and it turns out, this is the 4th time it's happened! Each time B6 fixed it, with ever larger doses. (My memory wasn't so good til I looked back...and remembered the details through the fog...)
My mom and child have had B6 problems, too, with a tendency to pick up toxins, and crappy methylation genes and glutathione production. The explanation I keep getting from our docs is it's used everywhere in methylation to detox, so we use it up fast.
But 400mg a day feels ridiculous...
I started digging into what B6 does and was quite surprised. B6 does a LOT of things...
One thing is that it's instrumental in sphingolipid production.
Which leaves me wondering if perhaps my sphingolipid production has been crappy for the past 5 years, leading to my CFS problem....
It also seems to be instrumental in antibody production, and my immune system seems to be asleep at the wheel...
Does any of this resonate with any of you? With the hundreds of posts I've seen here on PR on methylation, glutathione, and other Bs, I just haven't noticed much on B6 and wonder if it's important to anyone else but me.
The sphingolipid piece makes me wonder in light of Naviaux's recent findings...
Thanks for any thoughts or comments ...
Does B6 matter?
I've had high serum ferritin for over a year. My doctor thinks it's due to my chronic infections, but ran an iron study to be sure. The results I had indicated either hemochromatosis or B6 deficiency anemia. I'm compound heterozygous for the 2 common HFE mutations, but my doctor said most people he'd seen with it had serum ferritin over 1000, which mine wasn't.
Hematocrit, MCHC, and sed rate had dropped, which seem to be related - looked like B6 deficiency was impacting heme metabolism, so hemoglobin wasn't picking up iron to be able to carry oxygen around in my red blood cells, which were misshapen.
We decided to up my P5P dose to 400mg, and sure enough my iron numbers are normalizing... BUT...
I reviewed my lab results for the past 5 years, and it turns out, this is the 4th time it's happened! Each time B6 fixed it, with ever larger doses. (My memory wasn't so good til I looked back...and remembered the details through the fog...)
My mom and child have had B6 problems, too, with a tendency to pick up toxins, and crappy methylation genes and glutathione production. The explanation I keep getting from our docs is it's used everywhere in methylation to detox, so we use it up fast.
But 400mg a day feels ridiculous...
I started digging into what B6 does and was quite surprised. B6 does a LOT of things...
One thing is that it's instrumental in sphingolipid production.
Which leaves me wondering if perhaps my sphingolipid production has been crappy for the past 5 years, leading to my CFS problem....
It also seems to be instrumental in antibody production, and my immune system seems to be asleep at the wheel...
Does any of this resonate with any of you? With the hundreds of posts I've seen here on PR on methylation, glutathione, and other Bs, I just haven't noticed much on B6 and wonder if it's important to anyone else but me.
The sphingolipid piece makes me wonder in light of Naviaux's recent findings...
Thanks for any thoughts or comments ...