Interesting...it seems like some of those other meds may be viable at first glance although I’m guessing protein binding or other factors limit the ability of them in their antiviral capacity.
Yes, I've done similar calculations on some of the other drugs, and unfortunately it turns out that due to factors like the maximum safe dose and protein binding issues, you just can't match the concentrations used in vitro.
Prozac is actually a reasonable antiviral for coxsackievirus B, if you do the calculations. But I think only for infections in the brain, as Prozac accumulates in the brain at far higher levels than the rest of the body.
But disappointedly, Dr Chia tried Prozac for his enterovirus ME/CFS patients some years back, but I never heard of any success stories.
Guanidine is a potent enterovirus antiviral in vitro, but due to severe toxicity, cannot be used in humans.
So it sounds like there’s essentially no options for Coxsackie besides the treatments that Dr Chia uses?
I systematically went through the dozens of enterovirus antiviral substances I listed in
this post, trying to find ones which might be effective in vivo, using the same calculation as I did above (it took months of work!). But unfortunately I found nothing that was potent in vivo, even though many substances were pretty potent in vitro.
The only thing that might be promising in that list is an obscure anti-cancer compound called OSW-1 (a natural substance from bulbs of the Ivory Coast lily). OSW-1 is an incredibly potent broad-spectrum antiviral in vitro, with an EC50 concentration of just 0.0021 μg/ml.
Typically the EC50 for viable antiviral substances is in the range of say 0.1 to 10 μg/ml, so you can see that OSW-1 is potent in tiny amounts. Although if OSW-1 turns out to have a high plasma protein binding, this can weaken its effects in vivo.
Unfortunately I could not find any sources of OSW-1 that sell to the public, nor any animal studies, nor any information about its safety. And Ivory Coast Lilies only contain a very tiny amount of OSW-1, just 0.0027%.