I have acute onset ME. Was a previously healty adult with no gut problems and no signs of lympathic problems. My symptoms were mainly viral
I was exactly the same, although I’ve retrospectively realised that my energy levels weren’t what they might have been for a reason e.g. when I
really pushed myself at sport I couldn’t quite keep up with others (tennis squad – 6 hours tennis a week proved too much)
ME, as you probably know, appeared in epidemics in the 20 Century. I can't see how your factors could explain the epidemics
It’s also been associated with the American civil war, WWI, and the 1st Gulf War, all three of which involved toxic agents. If Perrin is correct, and my theory feeds off his theory, then toxic stress can be a cause of the persistence of CFS/M.E. type symptoms
To put it in the context of epidemics - if there is a failure of the lymphatics to adequately deal with sudden and pronounced action on the system (all sorts of immune-response-linked bits and bobs e.g. used white blood cells go into the lymphatics to be broken down), plus the aggravating factor of inflammation (may be intrinsic and/or extrinsic), then there is a risk of fundamental breakdown of the proper drainage mechanisms due to thoracic duct varicosity, leading to ’backflow’:
Perrin theorises that the propensity for a failure to deal with such an influx relates to postural defects, commonly found in PWME (myself, and the friends I’ve examined, included):
Also can't see how it would explain the why ME is spreading to the in-laws of my family
I can’t comment on such things without detailed knowledge of individual PWME
I think some of this might be right, but its likely that its not complete nor fully right, and it will require further studies to investigate
That’s my position too, virtually none of the pieces of the puzzle have been fully/rigorously investigated, but there are compelling signs here there and everywhere that the various constituent parts of my theory ought to be investigated, both in isolation, as well as as part of an integral investigative approach
Gluten can cause celiac disease but also non-celiac wheat sensitivity (for which I think a paper was published recently showing this)
I have non-Coeliac wheat sensitivity, and my grandfather had Coeliac disease, many of the PWME I have spoken to have similar intolerances ~ this feeds into the Metabolic Acidosis/Candidiasis part of the picture
The PRBs (there are at least 4) also bind dietary tannins, which are toxic
Thanks for the info, very interesting - will definitely look into this
High elastase is associated with high lmw RNaseL in CFS, and together are a potential biomarker
I’m not too sure about this stuff (my brain isn’t the best atm due to a cold, and my scientific mind is fairly infantile anyway, but I did stumble across RNaseL and included a bit about it on
my page yesterday)
I think the model presented here might be well served by examining it in light of recent work by Maes on autoantibodies, and also some stuff I am slowly assembling on secondary effects of LPS from the gut, including translocation of gamma delta T cells
Thanks, any further input/critical analysis would be wonderful
I'm confused, what was the study and where's the paper?
It’s a literature review based quasi-thesis rather than an academic experimental research paper
Mass outbreaks would be related to exposure to either specific infections or toxins that are more likely to throw the system out of balance and act as a trigger
Agreed
I can see it's being keenly received and it's not my website, but the headline thread on this forum explicitly states that it is for published research papers
My article falls under
“abstracts … of published research”, and discussion of them – it’s a discussion of contemporary research (inc. various papers referenced directly by way of web-links)
I have just noticed that you have a copyright sign at the bottom of your first post. Have you copyrighted the ideas put forward here? Wouldn't that imply it was an original idea, rather than a pulling together of other peoples work?
The component processes are not, for the large part, original ideas ~ however the theory/thesis as a whole, is, to my knowledge, unique
They are the fairer sex and their gut lining is more fragile than most men's
This I did not know!
Women, I'm guessing, have a weaker BBB than men, allowing more HPA interference than in men
Hmm, wonder if that’s true(?)
Thanks for your comments all