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Good afternoon to all.
I have been asked where the markers I comment on in this thread can be made. I have found that Mayo Medical Laboratories perform one of the tests I indicate: CD4+ HLA-DR+ activated T lymphocytes and CD8+ HLA-DR+ activated T lymphocytes. This test, if the levels are reduced, indirectly indicates a decrease in the antigenic presentation II of the antigen lending cells (B lymphocytes are antigen presenting cells). This explains the immunodepression caused by the Epstein Barr virus, which I comment on in the article. In other words, the latent virus found in B lymphocytes prevents these B lymphocytes from presenting antigens to the T lymphocytes to activate them by means of the latent proteins of this virus.
I recommend reading the link to the test website: https://asantelab.testcatalog.org/show/TCP
Among the uses that put this analysis I highlight the following:
"Evaluation of T-cell immune competence (presence of memory and activated T cells) in patients with recurrent infections".
These comments are also noteworthy:
"Activation of human T cells is critical for the optimal and appropriate performance of T-cell functions within the adaptive immune response. Activated naive T cells undergo proliferation, as well as subsequent differentiation into effector T cells, and are capable of producing cytokines that can modulate the immune response in a variety of ways.(8) There are several markers associated with T-cell activation, but those most commonly used include CD25 (IL-25R)(8) and MHC class II.(9) Additionally, the expression of the costimulatory molecule CD28 augments the T-cell activation response.(10)".
"Reduction in activated T cells can also indicate a reduced T-cell immune competent state.
This would demonstrate the immunological problems we have. For now all the tests I have seen of people with CFS/MS who have been tested for activated T lymphocytes have come out low.
In the United States, you can do it in this lab: Mayo Medical Laboratories
In Spain you can do it in Megalab, analizA and Cerba
I would be grateful if other people from other countries could tell me in which laboratories they can do it, to complete the list.
Examples:
I have been asked where the markers I comment on in this thread can be made. I have found that Mayo Medical Laboratories perform one of the tests I indicate: CD4+ HLA-DR+ activated T lymphocytes and CD8+ HLA-DR+ activated T lymphocytes. This test, if the levels are reduced, indirectly indicates a decrease in the antigenic presentation II of the antigen lending cells (B lymphocytes are antigen presenting cells). This explains the immunodepression caused by the Epstein Barr virus, which I comment on in the article. In other words, the latent virus found in B lymphocytes prevents these B lymphocytes from presenting antigens to the T lymphocytes to activate them by means of the latent proteins of this virus.
I recommend reading the link to the test website: https://asantelab.testcatalog.org/show/TCP
Among the uses that put this analysis I highlight the following:
"Evaluation of T-cell immune competence (presence of memory and activated T cells) in patients with recurrent infections".
These comments are also noteworthy:
"Activation of human T cells is critical for the optimal and appropriate performance of T-cell functions within the adaptive immune response. Activated naive T cells undergo proliferation, as well as subsequent differentiation into effector T cells, and are capable of producing cytokines that can modulate the immune response in a variety of ways.(8) There are several markers associated with T-cell activation, but those most commonly used include CD25 (IL-25R)(8) and MHC class II.(9) Additionally, the expression of the costimulatory molecule CD28 augments the T-cell activation response.(10)".
"Reduction in activated T cells can also indicate a reduced T-cell immune competent state.
This would demonstrate the immunological problems we have. For now all the tests I have seen of people with CFS/MS who have been tested for activated T lymphocytes have come out low.
In the United States, you can do it in this lab: Mayo Medical Laboratories
In Spain you can do it in Megalab, analizA and Cerba
I would be grateful if other people from other countries could tell me in which laboratories they can do it, to complete the list.
Examples:
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