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Created in 2008, Phoenix Rising is the largest and oldest forum dedicated to furthering the understanding of and finding treatments for complex chronic illnesses such as chronic fatigue syndrome (ME/CFS), fibromyalgia (FM), long COVID, postural orthostatic tachycardia syndrome (POTS), mast cell activation syndrome (MCAS), and allied diseases.
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Hip, do you know of any research which tries to answer why the 1% get symptomatic polio, is there any difference in genetics or whatever?
I would imagine, though, that the crucial factor which determines whether poliovirus causes no harm at all, or causes serious injury, is whether this virus is able to enter the central nervous system during the acute infection.
But there are backdoors into the brain that viruses can use. In the case of enterovirus, the entry route into the brain is most likely the vagus nerve, which runs from the stomach to the brain. Dr Chia in one of his presentations points out that enterovirus can travel along the vagus, from stomach to brain, in only 3 days.
I don't believe in the psychological theories of ME/CFS, but there are several studies showing lots of ME/CFS patients experienced major chronic stress (eg from events like divorce) in the year before they developed ME/CFS. Now we know that chronic stress reduces immunity, so if you were unlucky enough to catch a potentially nasty pathogen like coxsackievirus B or poliovirus during a time of chronic stress, perhaps this might allow the pathogen to do a lot more harm than normal.
Full-page article in today's New York Times "Scientists Find Clues to Mysterious Paralysis in Children" compares the two AFM studies, Nature Medicine's to Lipkin's, with quotes from Avi Nath at NINDS.It would be useful to compare the ME/CFS findings from both groups-- they were similar in their AFM studies, 70% and 80% respectively.
@Hip to your point perhaps these experts would benefit from reading today's NYTimes AFM article :These so-called experts obviously did not pay much attention in class when learning about enterovirus: those who know about enterovirus will tell you that you usually do not find enterovirus in the cerebrospinal fluid during an enterovirus brain infection.
Speaking of Avi Nath, wonder if he's testing his ME/CFS Clinical Study participants with VirScan, VirCapSeq-VERT, and/or SeroChip microarrays?
do you know of any research which tries to answer why the 1% get symptomatic polio, is there any difference in genetics or whatever?
My mother have been struggling with post polio, and as we are two children with me/ cfs
would you describe the similarities or differences between post-polio syndrome and ME/CFS?
So: except from the damage nerves, it's said from doctors, and I believe from my own observations, that postpolio and me/cfs is as close as can be. Maybe the same sickness.
From observation, but with very, very few participants, I believe one might inherit this weakness from a polio parent.
For some reason, I believe you inherit mother, but perhaps not father.