60% of supplemental choline is consumed by gut bugs even in healthy people. I do not have data on inositol, but it wont be better. Now, there are doctors (e.g. Prof Meirleir) who cure a part of the CFS patients by eradicating bad bugs in the gut (and some of these didnt know they have gut probs!). So from here on it is IMO no good idea to take such things orally. I did that long time ago and noticed always improvements at first, then deterioration after a while (incl brain fog).
All people are different, but for me the big difference is taking things transdermally or orally. Taking supplements orally isnt a good idea because bugs are superb at consuming isolated / processed nutrients (and not so good at consuming real food, which btw gets decomposed into elementary nutrients often only in the very last momont before resorption, think brush border enzymes).
My gut is unfortunately so sick, that even real food containing the inositol, choline, etc wont work, though damage is slower than from oral supplements. But transdermal works: Zero brain fog, only benefits.
Here my first successful transdermal lecithin self-treatment. But its a hassle as granules do not resolve well. A more simple thing I found out meanwhile: distribute a teaspoon of NOW sunflower lecithin powder on skin (e.g. a thigh when sitting) and rub it in with "magnesium oil" (Mg-Cl bath crystals resolved in water. The Mg-Cl helps resorption, because it dilates skin blood vessels, the water resolves the lecithin. Buy a good quality cleaned Mg-Cl bath salt, otherwise it will eat your skin...
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And yes, there you have also choline included, let that combo be extra beneficial or not, I need both.
