Why Antidepressants Don’t Work for Treating Depression
Here’s some depressing recent medical news: Antidepressants don’t work.
What’s even more depressing?
The pharmaceutical industry and Food and Drug Administration (FDA) have deliberately deceived us into believing that they DO work.
As a physician, this is frightening to me. Depression is among the most common problems seen in primary-care medicine and soon will be the second leading cause of disability in this country.
The study I’m talking about was published in a recent issue of “The New England Journal of Medicine.”
It found that drug companies selectively publish studies on antidepressants. They have published nearly all the studies that show benefit -- but almost none of the studies that show these drugs are ineffective. (1)
That warps our view of antidepressants, leading us to think that they do work. And it has fueled the tremendous growth in the use of psychiatric medications, which are now the second leading class of drugs sold, after cholesterol-lowering drugs.
And it’s even worse than it sounds, because the positive studies hardly showed benefit in the first place.
For example, 40 percent of people taking a placebo (sugar pill) got better, while only 60 percent taking the actual drug had improvement in their symptoms. Looking at it another way, 80 percent of people get better with just a placebo.
That leaves us with a big problem -- millions of depressed people with no effective treatments.
Let’s take a closer look at depression.
“Depression” is simply a label we give to people who have a depressed mood most of the time, have lost interest or pleasure in most activities, are fatigued, can’t sleep, have no interest in sex, feel hopeless and helpless, can’t think clearly, or can’t make decisions.
But that label tells us NOTHING about the cause of those symptoms.
In fact, there are dozens of causes of depression -- each one needing a different approach to treatment.
Depression is not one-size-fits-all.
But it’s very common.
Women have a 10 to 25 percent risk and men a 5 to 12 percent risk of developing severe major depression in their lifetime. (2)
One in ten Americans takes an antidepressant. The use of these drugs has tripled in the last decade, according to a report by the federal government. In 2006, spending on antidepressants soared by 130 percent.
But just because antidepressants are popular doesn’t mean they’re helpful.
Unfortunately, as we now see from this report in “The New England Journal of Medicine,” they don’t work and have significant side effects.
Most patients taking antidepressants either don’t respond or have only partial response.
In fact, success is considered just a 50 percent improvement in half of depressive symptoms. And this minimal result is achieved in less than half the patients taking antidepressants.
That’s a pretty dismal record. It’s only made worse by the fact that 86 percent of people taking antidepressants have one or more side effects, including sexual dysfunction, fatigue, insomnia, loss of mental abilities, nausea, and weight gain.
No wonder half the people who try antidepressants quit after 4 months.
Now I want to talk to you about the reasons why doctors and patients have been deceived by the “antidepressant hoax.”
Despite what we have been brainwashed to believe, depression is not a Prozac deficiency!
Drug companies are not forced to publish all the results of their studies. They only publish those they want to.
The team of researchers that reported their findings in “The New England Journal of Medicine” took a critical look at all the studies done on antidepressants, both published and unpublished.
They dug up some serious dirt.
The unpublished studies were not easy to find. The researchers had to search the FDA databases, call researchers, and hunt down hidden data under the Freedom of Information Act.
What they found was stunning.
After looking at 74 studies involving 12 drugs and over 12,000 people, they discovered that 37 of 38 trials with positive results were published, while only 14 of 36 negative studies were published.
And those that showed negative results were in the words of the researchers, “published in a way that conveyed a positive outcome.”
That means the results were twisted to imply the drugs worked when they didn’t.
This isn’t just a problem with antidepressants. It’s a problem with scientific research. Some drug companies even pay or threaten scientists to not publish negative results on their drugs.
So much for “evidence-based” medicine!
Most of the time, we only have the evidence that the drug companies want us to have. Both doctors and patients are deceived into putting billions of dollars into drug companies’ pockets, while leaving millions with the same health problems but less money.
The scientific trust is broken. What can we do?
Unfortunately, there is no easy answer.
But I do think Functional Medicine, on which my approach of UltraWellness is based, provides a more intelligent way of understanding the research.
Rather than using drugs to suppress symptoms, Functional Medicine helps us find the true causes of problems, including depression.
I see this in so many of the patients I have treated over the years. Just as the same things that make us sick also make us fat, the same things that make us sick also make us depressed.
Fix the causes of sickness -- and the depression takes care of itself.
Just look at these few cases:
A 23-year-old had been anxious and depressed most of her life and spent her childhood and adolescence on various cocktails of antidepressants.
Turns out, she suffered from food allergies that made her depressed. Food allergies cause inflammation, and studies now show inflammation in the brains of depressed people.
In fact, researchers are studying powerful anti-inflammatory drugs used in autoimmune disease such as Enbrel for the treatment of depression.
So after she eliminated her IgG or delayed food allergies, her depression went away, she got off her medication -- and she lost 30 pounds as a side effect!
A 37-year-old executive woman struggled for more than a decade with treatment-resistant depression (meaning that drugs didn’t work), fatigue, and a 40-pound weight gain.
We found she had very high levels of mercury. Getting the mercury out of her body left her happy, thin, and full of energy.
A 49-year-old man with severe lifelong depression had been on a cocktail of antidepressants and psychiatric medication for years but still lived under a dark cloud every day, without relief.
We found he had severe deficiencies of vitamin B12, B6, and folate. After we gave him back those essential brain nutrients, he called me to thank me. Last year was the first year he could remember feeling happy and free of depression.
These are just a few of the dozens of things that can cause depression.
The roots of depression are found in the 7 keys to UltraWelless and the 7 fundamental underlying imbalances that trigger the body to malfunction.
As we now see, taking antidepressants is not the answer to our looming mental health epidemic.
In the meantime, here are a few things that account for a lot of depression -- and how to fix them.
- Try an anti-inflammatory elimination diet that gets rid of common food allergens (see “The UltraSimple Diet”)
- Check for hypothyroidism
- Treat vitamin D deficiency with at least 2,000 to 5,000 U a day of vitamin D3
- Take omega-3 fats in the form of 1,000 to 2,000 milligrams (mg) a day of purified fish oil. Your brain is made of up this fat.
- Take adequate B12 (1,000 micrograms, or mcg, a day), B6 (25 mg) and folic acid (800 mcg). These vitamins are critical for metabolizing homocysteine which can play a factor in depression.
- Get checked for mercury
- Exercise vigorously five times a week for 30 minutes. This increases levels of BDNF, a natural antidepressant in your brain.
(1) Turner EH et al. 2007. Selective publication of antidepressant trials and its influence on apparent efficacy. New England Journal of Medicine. 358: 252-260.
(2) Eaton WW, Kalaydjian A, Scharfstein DO, Mezuk B, Ding Y. 2007. Prevalence and incidence of depressive disorder: the Baltimore ECA follow-up, 1981-2004. Acta Psychiatr Scand.116(3):182-188.