I don't know to what degree there is permanent damage. I am concerned about the mitochondria in general.
hi Rich,
thanks for all the info.
I am also concerned about permanent/semi-permanent nerve damage. Can you discuss this?
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I don't know to what degree there is permanent damage. I am concerned about the mitochondria in general.
I do however completely agree that ME/CFS is due to a broken down detox system that has completely stalled
Hi, Ian.
Over the past 15 years, I have encountered a few cases in which dental issues certainly were key. Some involved constantly sore or swollen lymph nodes, which were corrected after the infection was cleared out of the gums. And mercury in amalgams definitely is a source of mercury buildup in the body, after onset if not before. There could well be "stealth" dental problems going on in other cases.
Best regards,
Rich
Hi, WillowJ.
Peripheral nerves have quite a bit of capability to regenerate, so if the pathophysiology is fixed, I'm hopeful that they can come back alright. I think the central nervous system is of more concern, because I think only the hippocampus has been found to be able to produce new neurons, and excitotoxicity can destroy neurons. I recall that Dr. Cheney used to justify his use of Klonopin (even though it can be habit-forming and can be difficult to get off of) by saying that he wanted to preserve the brain so that his patients would still have one when they recovered from CFS. I'm looking forward to finding out whether the new "Calm Down" spray that Amy Yasko is coming out with will effectively control excitotoxicity, because this is something that is really needed, in my opinion.
Best regards,
Rich
"Again, based on experience up to now, I would say that the fundamental pathophysiology is the same in nearly all cases of ME/CFS, and it involves a chronic vicious circle mechanism that includes depletion of glutathione, a functional deficiency of vitamin B12, a partial block of methionine synthase (which links the methylation cycle with the folate metabolism), and loss of folates from the cells. Essentially everything else in ME/CFS (other than direct effects of pathogens or initial toxins) stems from this vicious circle. This is elaborated in the Swedish seminar here: http://iaomt.media.fnf.nu/2/skovde_2011_me_kroniskt_trotthetssyndrom/$%7Bweburl%7D"
At this moment and my own personal experience I don't agree with any of this. I have been on
5mg of MB12 Jarrow's
7.5-15mg Deplin or Leucovorin
3-4gm of NAC
200mg of S-acetyl-gluthatione
daily for over a year. All this plus Valcyte and Famvir/Valtrex, I did not feel that it got to the main cause of my CFS. It was when I took detox specific supplements (bile, diuretic, fiber) that I really felt better and that I had recovered, sometimes from the very first dosage.
I do however completely agree that ME/CFS is due to a broken down detox system that has completely stalled and really needs to be seen to constantly to get it going. Everything other facet of ME/CFS symptoms start from this.