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    Created in 2008, Phoenix Rising is the largest and oldest forum dedicated to furthering the understanding of and finding treatments for complex chronic illnesses such as chronic fatigue syndrome (ME/CFS), fibromyalgia (FM), long COVID, postural orthostatic tachycardia syndrome (POTS), mast cell activation syndrome (MCAS), and allied diseases.

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What's the most similar disease to ME/CFS for assessing off-label treatment options?

What's the most similar disease to ME/CFS for assessing off-label treatment options?

  • Rheumatoid arthritis

    Votes: 0 0.0%
  • Multiple sclerosis

    Votes: 3 37.5%
  • Sjorgen's syndrome

    Votes: 0 0.0%
  • Lupus erythematosus

    Votes: 0 0.0%
  • Crohn's disease

    Votes: 2 25.0%
  • Scleroderma

    Votes: 0 0.0%
  • Myasthenia gravis

    Votes: 0 0.0%

    Votes: 0 0.0%
  • Guillain Barre

    Votes: 3 37.5%

  • Total voters


Senior Member
Southern California
To be clear I'm talking about post-viral ME/CFS of a likely autoimmune origin.


There are many drugs that few ME/CFS patients have tried, and many people with "chronic fatigue" inadvertently mischaracterize themselves in drug review databases. As a result there are a lot of nebulous diagnoses and limited treatment entries when ME/CFS is used as a critieria for drug review sites.

So recently, while trying to find a good immunosuppressive drug, I've been looking at other major autoimmune disease treatment reviews to see what puts people into remission in those conditions.

Which disease is the best analogue? I don't think anyone knows for sure, but my hope is that some crowdsourced wisdom will provide a degree of clarity. Thus this poll.


If an option is not listed here, please post it below.


PS - I've purposefully left off POTS/dysautonomia, MCAS, MCS, Lyme, and fibromyalgia because they are so commonly co-morbid and tend to suffer from the same review issues as ME/CFS.