datadragon
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One thing you might want to look into are Sigma 1 agonists. Sigma 1 agonists are being trialed for Huntington’s as ER stress inhibitors and if I’m not mistaken Fluvoxamine has shown promise for COVID/LC due to its Sigma 1 agonism
I would look at that closer as I only had a moment to look. The below suggests Sigma 1 can induce pain and ER Stress. That may be good for certain things but perhaps not for reducing exercise intolerance ME/CFS by reducing ER Stress.
CBD activation of TRPV1 induces oxidative signaling and subsequent ER stress in breast cancer cell lines
https://pubmed.ncbi.nlm.nih.gov/33604949/and
TRPV1 channels and the progesterone receptor Sig-1R interact to regulate pain. Here we show that TRPV1 physically interacts with the Sigma 1 Receptor (Sig-1R), a chaperone that binds progesterone, an antagonist of Sig-1R and an important neurosteroid associated to the modulation of pain. Antagonism of Sig-1R by progesterone results in the down-regulation of TRPV1 expression in the plasma membrane of sensory neurons and, consequently, a decrease in capsaicin-induced nociceptive responses. This is observed both in males treated with a synthetic antagonist of Sig-1R and in pregnant females where progesterone levels are elevated. https://www.pnas.org/doi/10.1073/pnas.1715972115 From my post here: https://forums.phoenixrising.me/thr...acute-pain-nejm-08-03-2023.90696/post-2442397