could you please share what happened when you took vit d orally?
It's a long story.
This thread details how some people with ME/CFS get extremely tired from taking Vitamin D--I think one person even said it happened when they got exposed to sunlight. And yes, I was one one of the people it made quite tired.
Vitamin A helped with fatigue to some degree, but not enough on its own. Vitamin MK-4 (a kind of vitamin K) helped with problems from calcium excess like headaches. The star player ended up being AKBA* (alpha keto benzoic acid), a derivative of frankincense, which along with vitamin A removed fatigue as a side-effect of vitamin D.
Unfortunately, vitamin D also caused huge problems concentrating, which is why I haven't posted much since my vitamin D experiment. Weirdly, stopping vitamin d (it's been months now) hasn't brought my brain back, so my current assumption is that my problems focusing were more of an indirect effect of the vitamin D than a direct effect.
In addition to all this, vitamin d weirdly seemed to cause a boron deficiency--weirdly, because boron seems to increase the active form of vitamin d. All in all, it seemed like after a while taking vitamin D would cause symptoms of vitamin d deficiency: what some people refer to as "ammonia" symptoms, in my case diarrhea, a feeling like my blood or lymph was stuck--very uncomfortable--and depression. This would be alleviated by taking boron. Unfortunately, boron depletes riboflavin, and I could never take enough boron to maintain high vitamin d levels without taking so much boron that I had symptoms of riboflavin deficiency. This was why I stopped taking oral vitamin D.
---
*I think vitamin d makes some of us tired because vitamin d works together with TGF-beta (
high in some people with CFS) to increase 5-lipoxygenase activity--at least
in myeloid cells. 5-lipoxygenase increases production of some inflammatory mediators, and I think this is how it could be making us tired. This theory is backed up by my success using AKBA to prevent fatigue as a side-effect of vitamin d.
As a side-note, the long-term benefits of this strategy are worth debating. Upregulating 5-lipoxygenase (production?) is part of our immune response to...something. Should we be trying to undercut this so that we can avoid vitamin-d side-effects? I'm not sure.