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Very bizarre TH17 immune response

Blazer95

Blazer95

..and we built castles in the Sky.
Messages
269
Location
Germany
Hey forum friends,

i already have a thread about this but I feel like i wanted to give this topic more room, I hope thats okay with you. I do not mean to spam or bloat up the forum traffic I am just genuinely interested in understanding these topics - I really hope thats okay with you.

I did a lot of new laboratory tests and the results seem to be odd. I expected the TH1 immune response to be too high or too low as a reaction on chronic infectious stuff but it was perfectly fine. The issue was somwhere else, where it wasnt expected and I havent found anything in particular about a th17 or th2 deficiency on the web.

Here's the results:

Histamine (+) 75,1 (<65,5) µg/l
TNF-alpha (+) 8,4 (<8,1) ng/l
IP-10 (interferon gamma induced protein) 31,6 (<300) pg/ml

TH1/TH2/TH17:
IFN-g (TH1) 631 (374-1660) pg/ml
IL-4 (TH2) 17,5 (28-141) pg/ml
TH1/TH2 Ratio: 36,1 (+) (6,1-21,0)
IL-2 (TH) 171 (94-347) pg/ml
IL17 (TH17) (-) 17,1 (49,0-446) pg/ml
IL-10 (Treg) 367 (274-1323) pg/ml
 
Blazer95

Blazer95

..and we built castles in the Sky.
Messages
269
Location
Germany
For everyone interested my constant hunger for informations has found this study, what do you think?

https://pubmed.ncbi.nlm.nih.gov/25078944/

All of the polysaccharide fractions tested induced IL-17 production at different concentration levels.
Click to expand...

So theoretically Reishi could induce a IL-17(Th17) immune response according to this study.

Further Reishi seems to have little to no effect on IL-4 (Th2), but other healing mushrooms could be beneficial:
https://journal.waocp.org/article_29489.html
The data is very conflicting however. In their graphics IL-4 seemed to elevate with further beta-glucan intake but the text said that with IL-12 induction of beta glucan the IL-4 would become supressed. So maybe beta glucan can increase IL-4 in numbers but decrease its functionality? We have to be careful.
 
Blazer95

Blazer95

..and we built castles in the Sky.
Messages
269
Location
Germany
LINE said:
Have you checked mineral status and vitamin status. Antioxidants?
Click to expand...
I have checked and i always seem high in caclium and low in copper and magnesium. my glutathione levels are being checked and the lab values should return in 10 days ( detoxification )

What is interesting however that the active form of vitamin D named Calcitriol seems to heavily impair IL-17 secretion:
https://en.wikipedia.org/wiki/T_helper_17_cell
The active form of vitamin D (1,25-Dihydroxyvitamin D3) has been found to 'severely impair' [37] production of the IL-17 and IL-17F cytokines by Th17 cells.
Click to expand...

My Calcitriol is actually borderline elevated so this could heavily contribute to this issue.

It seems that the subset of ME/CFS patients that are not becoming ill anymore (e.g. common cold) have this downstream of events:

inflammation -> vitamin d receptor disruption -> calcitriol elevation -> IL-17 impairment -> impaired immune response
yeah-science.jpg
 
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