• Welcome to Phoenix Rising!

    Created in 2008, Phoenix Rising is the largest and oldest forum dedicated to furthering the understanding of and finding treatments for complex chronic illnesses such as chronic fatigue syndrome (ME/CFS), fibromyalgia (FM), long COVID, postural orthostatic tachycardia syndrome (POTS), mast cell activation syndrome (MCAS), and allied diseases.

    To register, simply click the Register button at the top right.

Valycte Question


Senior Member
For those of you who are on Valycte, how long did it take before you noticed a difference or improvement?

Just started 450 mg, 2 x a day about a week ago.....thanks!
I am somewhat different than most. I started Valcyte 1800mg At the end of the 4th day I opened my eyes wide and said (out loud) "I feel different". And many of my autonomic symptoms started to improve. After 2 weeks, the dose was reduced to 900mg and I went downhill. Later back up to 1800mg and the very same routine. At the end of the 4th day "I feel different". I have been on that dose for 10 days and better each day. But we are waiting for blood test results on my liver (may be a problem). If so, back to a lower dose.
Everyone I have heard of has to be on it for months, although Jennifer Brea (Unrest) took Valcyte and her movie implied that she had very fast improvement.


Senior Member
It was after about 4 1/2 months of taking it that I woke up and thought "I don't feel as sick anymore." It was the day after Thanksgiving. I was so grateful. I am currently on Valtrex.... 500 mg twice a day. I tried to reduce it to once a day and that did not work.


Senior Member
Pacific Northwest
I started on 1.8g a day and my brain fog cleared during the first 30 days. My viral PCRs were negative after 5 months. I've been on it 9 months. My doctor just reduced it to 900mg today, and we're going to see how I do.