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Unveiling sulfation of vitamin D3


Senior Member
FEBS Lett. 2017 Aug;591(16):2417-2425. doi: 10.1002/1873-3468.12767. Epub 2017 Aug 9.
Sulfation of vitamin D3 -related compounds-identification and characterization of the responsible human cytosolic sulfotransferases.
Kurogi K1,2, Sakakibara Y2, Suiko M2, Liu MC1.
Author information
Department of Pharmacology, College of Pharmacy and Pharmaceutical Sciences, University of Toledo Health Science Campus, OH, USA.
Department of Biochemistry and Applied Biosciences, University of Miyazaki, Japan.
While 25-hydroxyvitamin D3 3-O-sulfate is known to be present in circulation, how it is generated in the body remains unclear. This study aimed to investigate its sulfation in major human organs and to unveil the responsible cytosolic sulfotransferases (SULTs). Of the vitamin D3 -related compounds tested, 25-hydroxyvitamin D3 and 7-dehydrocholesterol are preferentially sulfated by human organ cytosols. Among the 13 human SULTs, SULT2A1 shows sulfating activity toward all vitamin D3 -related compounds, whereas SULT1A1 and SULT2B1a/SULT2B1b show sulfating activity exclusively for, respectively, calcitriol and 7-dehydrocholesterol. These findings suggest that the metabolic pathway leading to the formation of 25-hydroxyvitamin D3 3-O-sulfate may be mediated by the sulfation of 25-hydroxyvitamin D3 or by the conversion of 7-dehydrocholesterol-3-O-sulfate in the skin.