Hi. Thanks for continued input. I was about to ask if anyone had other relevent studies they could find; i will look at the ones above on mTor. I went to the one on nmda; its good find, but likely the macrolide antibiotics are not exactly an nmda antagonist; rather, they seem to have found its protective at the nmda receptor against glutimate toxicity. but so far have only read the abstract. Anyway, a good find. have not been able to find similar articles; if anything, a couple of things that suggest the reverse- e.g. there was a report that macrolides inhibit the neuro protective effects of some immunosupressents. Will keep looking.
for memum: does your daughter have PANDA? i think i came across that all when looking for infectious and AI causes of increased dopamine in brain and saw that those antibodies your daughter has, presumably from molecular mimicry to strep infection, can cause increased dopamine levels. In your daughters case, the antibiotic might just be beating back the strep (or body proteins that cross react with strep) which should help.
was looking that erythromycin, like many macrolides, also has anti inflammatory and is an immuo modulator. it apparently decreases il-8 and possible tnf alpha.
i can now cofirm that off the antibiotic, my symtoms are coming rushing back: awakeings repeatedly with vertigo and strange head sensations, sleeplesness, pounding heart, feeling like i've drank 7 cups of coffee, headaches, hot flashes, night sweats, overstimulation.
but not sure i can live on the stuff. it did impair thinking, I already have elevated liver enzymes, and that stuff metabolized through liver, and the same t cell supression that may be beneficial in some ways may make my recurrent herpes return (some macrolides are apparently used specifically for immunosupression, particularly after organ transplants and they do mention risk of returning herpes viruses). This morning, i woke up with a burning rash on my chest. took a couple of pics of it. I do get dermographia anyway, so hard to know what to make of red blotches. but this burns not ithces and is not raised, so who knows what i might have st in motion from the antibiotic. I will have to await the next chapter...