JaimeS
Senior Member
- Messages
- 3,408
- Location
- Silicon Valley, CA
Hey, guys, I found this Julie Newton study... haven't taken a close look at it yet.
Here is the link to the full text.
Understanding Muscle Fatigue in Chronic Fatigue Syndrome
Gina Rutherford1 MSc , Philip Manning1 PhD, Julia L Newton MD, PhD 1,2
1Institute of cellular medicine, Newcastle University, Newcastle UK.
2 Newcastle hospitals NHS foundation trust, UK NIHR biomedical research centre in ageing and age related disease, Newcastle University, Newcastle UK
Introduction:
Chronic fatigue syndrome/ Myalgic Encephalomyelitis (CFS/ME) is a debilitating disorder of unknown aetiology and is characterised by severe disabling fatigue in the absence of an alternative diagnosis. Historically, there has been a tendency to draw psychological explanations for the origin of fatigue, however this model is at odds with findings that fatigue and accompanying symptoms may be explained by central and peripheral pathophysiological mechanisms, including effects of the immune, oxidative, mitochondrial and neuronal pathways. For example, patient descriptions of their fatigue regularly cite difficulty in maintaining muscle activity due to perceived lack of energy. This narrative review examines the literature for evidence of biochemical dysfunction in CFS/ME at the skeletal muscle level.
Looks like a rough draft with markups. I have no idea where it's posted, but Google Scholar alerted me... so it's posted somewhere.
-J
Here is the link to the full text.
Understanding Muscle Fatigue in Chronic Fatigue Syndrome
Gina Rutherford1 MSc , Philip Manning1 PhD, Julia L Newton MD, PhD 1,2
1Institute of cellular medicine, Newcastle University, Newcastle UK.
2 Newcastle hospitals NHS foundation trust, UK NIHR biomedical research centre in ageing and age related disease, Newcastle University, Newcastle UK
Introduction:
Chronic fatigue syndrome/ Myalgic Encephalomyelitis (CFS/ME) is a debilitating disorder of unknown aetiology and is characterised by severe disabling fatigue in the absence of an alternative diagnosis. Historically, there has been a tendency to draw psychological explanations for the origin of fatigue, however this model is at odds with findings that fatigue and accompanying symptoms may be explained by central and peripheral pathophysiological mechanisms, including effects of the immune, oxidative, mitochondrial and neuronal pathways. For example, patient descriptions of their fatigue regularly cite difficulty in maintaining muscle activity due to perceived lack of energy. This narrative review examines the literature for evidence of biochemical dysfunction in CFS/ME at the skeletal muscle level.
Looks like a rough draft with markups. I have no idea where it's posted, but Google Scholar alerted me... so it's posted somewhere.
-J