Thank you
@Hip ive looked at this list extensively. I'm going to try many, wish i could get ahold of dextro naltrexone. Many of the things on this list didn't work for me so far or had bad side effects.
There are in fact several different possible strategies contained within that list of drugs and supplements which inhibit microglia:
• You could try some of the drugs and supplements that simply lower
microglial activation.
• You could try
countering some of the factors that increase microglial activation. Lipopolysaccharide, interferon gamma and homocysteine all increase microglial activation.
• You could try some of the drugs and supplements that lower
the release of inflammatory cytokines from microglia.
• You could try some of the drugs and supplements that lower
the release of inflammatory cytokines from astrocytes. In studies, coxsackievirus B, a virus strongly linked to ME/CFS, has been found to infect astrocytes, and then cause the chronic release of inflammatory cytokines from these infected astrocytes. So perhaps inhibiting the release of inflammatory cytokines from astrocytes might be beneficial.
• You could try some of the drugs and supplements that help switch activated microglia from their
neurodestructive mode (the "kill mode") to the
neuroprotective mode (the "heal and repair" mode). Activated microglia do not have to operate in this neurodestructive mode, they can also operate in the neuroprotective mode. Drugs and supplements that help switch activated microglia to the neuroprotective mode include: genistein, sulforaphane and artesunate.