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Moderator Note: This thread was spun off from the thread on Media Coverage of Dr Alter's NIH Paper:
http://www.forums.aboutmecfs.org/sh...H-paper-post-stories-here&p=119450#post119450
I'm a bit out of touch with this thread but if this has already been posted in this or another thread, shout and I'll delete it.
Science Media Centre (SMC) Press Release
23 August 2010
http://www.sciencemediacentre.org/pages/press_releases/10-08-23_cfs_virus_pnas.htm
Expert reaction to PNAS study on virus sequences found in blood of chronic fatigue syndrome patients
This research, published in Proceedings of the National Academy of Sciences purports to find a link between a virus and chronic fatigue syndrome, although this is not the same virus as that implicated in similar recent discoveries.
--------------------------------------------------------------------------------
Prof Robin Weiss, Professor of Viral Oncology, University College London, said:
"The paper by Lo and colleagues in PNAS claims an association between a retrovirus of mice and human chronic fatigue syndrome. It is based on small numbers but it will provoke discussion. Let's hope it is not another claim like MMR and autism which didn't hold up, but I am sceptical of the claim. Different primers were used for the CFS samples and the controls in Figure 1 and the analysis does not appear to have been performed using blinded samples. Remarkably, the mouse retrovirus is not the same as the one linked to CFS in a report published last year. One should also bear in mind that no less than 4 negative reports on this topic (failing to find a retrovirus link) have been published this year from reputable scientific groups in the UK, The Netherlands and at the Center for Communicable Diseases & Prevention in Atlanta, USA."
Prof Myra McClure, Professor of Retrovirology & Honorary Consultant in GU Medicine, Imperial College London, said:
"The paper by Lo et al, communicated by Harvey Alter, is bound to baffle both virologists and CFS patients alike. In the first place, it is important to realise that this group have not detected the virus (XMRV) that claimed media attention after the publication of Lombardi's paper in Science last year. They describe murine leukaemia virus (MLV)-related sequences that are genetically distinct from XMRV. The second mystifying aspect of this paper is that, just as in the Science paper, these new virus sequences seem very easy to detect (after only single round PCR). Several other groups, including the CDC in Atlanta, have employed the same experimental protocol, yet have consistently failed to detect any retrovirus in CFS patients. In carrying out such studies it is always important that test samples and control samples are randomised prior to analysis and that they are tested blind. It would be reassuring to know that this was the case with this study. In view of the controversy that this paper will inevitably generate, the authors are sensibly cautious about the significance of their findings with respect to CFS."
Detection of MLV-related virus gag gene sequences in blood of patients with chronic fatigue syndrome and healthy blood donors, by Lo et al., published in the Proceedings of the National Academy of Sciences.
To contact the above please contact the Science Media Centre on 020 7670 2980
Note for editors
The Science Media Centre (SMC) is an independent venture working to promote voices, stories and views from the scientific community to the news media when science is in the headlines. Over 50 sponsors including scientific institutions, media groups, corporate organisations and individuals fund the Centre, with donations capped at 5% of the running costs to preserve its independence. The team at the Centre is guided by a respected Scientific Panel and Board of Advisors. This press release contains the personal opinions of those acknowledged; which represent neither the views of the SMC nor any other organisation unless specifically stated.
For more details see our website www.sciencemediacentre.org, please e-mail the Science Media Centre with your comments.
http://www.forums.aboutmecfs.org/sh...H-paper-post-stories-here&p=119450#post119450
I'm a bit out of touch with this thread but if this has already been posted in this or another thread, shout and I'll delete it.
Science Media Centre (SMC) Press Release
23 August 2010
http://www.sciencemediacentre.org/pages/press_releases/10-08-23_cfs_virus_pnas.htm
Expert reaction to PNAS study on virus sequences found in blood of chronic fatigue syndrome patients
This research, published in Proceedings of the National Academy of Sciences purports to find a link between a virus and chronic fatigue syndrome, although this is not the same virus as that implicated in similar recent discoveries.
--------------------------------------------------------------------------------
Prof Robin Weiss, Professor of Viral Oncology, University College London, said:
"The paper by Lo and colleagues in PNAS claims an association between a retrovirus of mice and human chronic fatigue syndrome. It is based on small numbers but it will provoke discussion. Let's hope it is not another claim like MMR and autism which didn't hold up, but I am sceptical of the claim. Different primers were used for the CFS samples and the controls in Figure 1 and the analysis does not appear to have been performed using blinded samples. Remarkably, the mouse retrovirus is not the same as the one linked to CFS in a report published last year. One should also bear in mind that no less than 4 negative reports on this topic (failing to find a retrovirus link) have been published this year from reputable scientific groups in the UK, The Netherlands and at the Center for Communicable Diseases & Prevention in Atlanta, USA."
Prof Myra McClure, Professor of Retrovirology & Honorary Consultant in GU Medicine, Imperial College London, said:
"The paper by Lo et al, communicated by Harvey Alter, is bound to baffle both virologists and CFS patients alike. In the first place, it is important to realise that this group have not detected the virus (XMRV) that claimed media attention after the publication of Lombardi's paper in Science last year. They describe murine leukaemia virus (MLV)-related sequences that are genetically distinct from XMRV. The second mystifying aspect of this paper is that, just as in the Science paper, these new virus sequences seem very easy to detect (after only single round PCR). Several other groups, including the CDC in Atlanta, have employed the same experimental protocol, yet have consistently failed to detect any retrovirus in CFS patients. In carrying out such studies it is always important that test samples and control samples are randomised prior to analysis and that they are tested blind. It would be reassuring to know that this was the case with this study. In view of the controversy that this paper will inevitably generate, the authors are sensibly cautious about the significance of their findings with respect to CFS."
Detection of MLV-related virus gag gene sequences in blood of patients with chronic fatigue syndrome and healthy blood donors, by Lo et al., published in the Proceedings of the National Academy of Sciences.
To contact the above please contact the Science Media Centre on 020 7670 2980
Note for editors
The Science Media Centre (SMC) is an independent venture working to promote voices, stories and views from the scientific community to the news media when science is in the headlines. Over 50 sponsors including scientific institutions, media groups, corporate organisations and individuals fund the Centre, with donations capped at 5% of the running costs to preserve its independence. The team at the Centre is guided by a respected Scientific Panel and Board of Advisors. This press release contains the personal opinions of those acknowledged; which represent neither the views of the SMC nor any other organisation unless specifically stated.
For more details see our website www.sciencemediacentre.org, please e-mail the Science Media Centre with your comments.